Research On Creation Of Engineered Nerve By Neural Tissue-Committed Stem Cells Derived From Bone Marrow

prevented due to lackness of excellent seeding cell, scaffolds, methods of plant. In this study, the neural tissue-committed stem cells was isolated from the bone marrow, then purifed and identified. On the ground, we planted the cells into the dcellularized nerve scaffold to produce tissue-engineered nerve, and used the production to heal injury of rat sciatic nerve by transplant. The results showed indicated that the tissue-engineered nerve created by the neural tissue-committed stem cells could restore conduction of injured peripheral nerve. The tissue-engineered nerve also provided with schwann cells and micro-condition adapt to restore injured nerve. It is suggested that the neural tissue-committed stem cells was ideal seeding cells for creation of tissue-engineered nerve. At the same time these results indicated Dcellularized nerve scaffold could be used as scaffold material to tissue-engineered nerve. Recently,there is no ideal method of treatment used to restore injured peripheral nerve. Tissue-engineered nerve is considered to be ideal method for treatment of this disease in the future. But the progress of shortage tissue-engineered nerve was...