Study On The Application Of Using Radiofrequency Ablation Technology In The Treatment Of Bone Tumors

Objective1. To evaluate computed tomography (CT)-guided radiofrequency (RF) ablation as a minimally invasive therapy for osteoid osteoma with regard to technical and clinical success and clinical analysis of the feasibility and clinical application.2. Use thermodynamic finite element method to study bone conduction heat 3D spatial distribution.3. To discuss the application prospects of CT-guided percutaneous radiofrequency ablation in the treatment of bone tumors.Methods1. Forty-two patients (age range, 13~46 y; mean age, 23.6 y) with osteoid osteomas (femur, n = 17; tibia, n = 13; pelvis, n = 7; humerus, n = 3; calcaneus, n = 1; vertebral body, n = 1) were treated with CT-guided RF ablation. Percutaneous therapy was performed with use of brachial plexus block or spinal anesthesia. After localization of the nidus with 1–3-mm CT sections, osseous access was established with either a 3.0-mm coaxial drill system(made by us) or an 12-gauge cooker needle. RF ablation was performed at 90°C for a period of 4–6 minutes with use of a rigid RF electrode with a diameter of 1.5 mm. The procedures were regarded as technically successful if the tip of the RF electrode could be placed within the center of the nidus and could be heated to the desired temperature. Preoperative and postoperative MRI scanning and contrast for Image. Clinical success of treatment was defined as permanent relief of pain and return to normal function without additional treatment. Visual Analog Scale Scale (VAS) as a clinical evaluation parameters. 6~24 months follow-up.2. Reference biomechanical finite element modeling method to establish human proximal tibial 3D finite element model of thermodynamics. A 15-centimeter-long fresh cow upper tibia is selected. Application of the German Siemens products LightSpeed 16 spiral along with human cross-sectional thickness 2mm into CT Scanners. Scanning photos DICOM format output, and through writing procedures for transfers JPG format. Use Tongji University Institute of Biomedical Engineering Laboratory prepared the digital image processing procedures CT images, point cloud acquisition. Acquisition of the file input point cloud reverse engineering software Geomagic entity model construction. Lane will Geomagic software generated solid model IGES files into the finite element analysis software Ansys 9.0 to construct finite element model of thermodynamics. Thermodynamic 3D finite element model of heat transfer, the model appearance bone structure set to body temperature(37℃). Bone designated area assumption 15mm diameter spherical regional heat, the temperature is 90℃, in the steady-state condition for the implementation of calculation.Results1. Parallel observed in all patients 24 hours after anti-infection treatment. After three days with pain. Non-steroidal anti-inflammatory drugs were given orally for three days after withdrawal. One week after treatment to alleviate pain symptoms. The pain disappeared in one month and were no recurrence follow-up 6~24 months. Postoperative MRI changed significantly in one month review, and VAS score decreased significantly. There was a significant (P <0.01).2. Different distance from the source of the cross-section of the temperature distribution density of different contours, the closer electrode, isogram more intensive, and irregular oval. Tibia in the sagittal plane, the more smiles around the temperature distribution certer isogram more intensitive, the more the farther sparse, and irregular oval.Conclusions1. CT-guided percutaneous RF ablation is a simple, minimally invasive, safe and highly effective technique for treatment of osteoid osteoma. Thus need for more accurate positioning and Multi-department cooperation.2. Vietnam close to the heat of the central marrow, thermodynamics isogram more intensive distribution, the greater the temperature gradient. Vietnam close to the heat source from the surrounding bone cortex, heat conduction lower, the smaller the temperature gradient. Ablation of the size and length of exposure needle alectrode and the space needle is closely related to the location.3. Radiofrequency ablation has a wide range of potential applications on the treatment of bone tumor. Which expects further basic and clinical trials.