The Relationship Between The Expression Of VEGF-C, Microvessel Density And Lymphatic Micrrovessel Desity, And Its Role In Metastasis Of Gastric Carcinoma

Objective To explore the relationship between the expression of VEGF-C, microvessel density (MVD), lymphatic microvessel density (LVD) and their role in metastasis of gastric carcinoma.Methods The expressions of VEGF-C mRNA in 62gatric carcinoma tissue specimens and 10 normal gastric tissues were determined by RT-PCR. Immunohistochemistry (SP) was used to detect the expressions of CD105 and VEGFR-3 in the tissues.Results the positive rate of VEGF-C in positive lymph node was significantly higher than that in negative lymph node (88% vs 21%,P<0.05); Compared with that without lymph node metastasis, LVD in positive lymph node increased significantly(6.15±1.61 vs 3.93±1.76 , P<0.05). LVD in positive VEGF-C was significantly higher than in negative VEGF-C(6.03±1.73 vs 4.05±1.71,P<0.05). MVD in the positive organ metastasis is higher than that in the negative organ metastasis(25.75±1.1 vs 20.15±4.70,P<0.05). Conclusions VEGF-C mediates metastasis of gastric carcinoma by the way of angiogenesis and lymphangiogenesis. MVD and LVD were significant predictive factors for metastasis of gastric carcinoma.