Study On Aztreonam Dry Powder Inhalations

Aztreonam is antibiotic of cephalosporins and carbapenems with high antibacterial activity to most Gram-negative bacteria. It is usually given as intravenous or intramuscular injections because of its huge dosage, and this can cause adverse effects generally. Our research made Aztreonam to micro powder which can be inhalered into pulmonary specially.Aztreonam Dry powder inhalations change the traditional route of administration totally. This preparation can reduce the dosage and the adverse effects, and elevate the therapeutic index with no first pass effect and no gastrointestinal degradation.On the basis of the fuzzy system theory, a complex factor was constructed to unite the dumping ratio, aerosolizing property, bulk density and repose angel to evaluate the qualities of Aztreonam Dry powder inhalations. Meanwhile, the UV and HPLC method was utilized to determine the Aztreonam in the Dry powder inhalations.Studies of the composition and preparation of Aztreonam Dry powder inhalations were emphases of this dissertation. A spray drying method was designed to make the Aztreonam Dry powder inhalations. The formulae were selected according to the complex factor which was constructed in the second part of this dissertation. The manufacture process was selected according to the recovery and the characteristics of the product.The research has studied the disposition of two different preparations in rats,one is intravenous injection with Aztreonam and the other is inhalation. The answer is Aztreonam Dry powder inhalations can accumulate generously and increase the concentration of durgs in pulmo. This preparation is also can reduce the amount of durgs in blood circulation and organs, so it can reduce the adverse effects.Studies on Aztreonam Dry powder inhalations indicate that using this as vector for antibiotic pulmonary delivery is feasible. Aztreonam Dry powder have wide applied space in antibiotic delivery.