| Objective :To explore the value of C-reactive protein (CRP) ,The serum level of CRP in hospitalized patients with acute exacerbations of chronic obstructive pulmonary disease ( COPD) was measured .Methods :Forty-three patients who were hospitalized with acute exacerbations of COPD were enrolled in about one year's observational period. The Anthonisen symptoms score was recorded and spirometry was conducted. Serum CRP was measured at the initial of hospitalization. and expectorated sputum samples was examined for three times in continuous way .The correlation between serum CRP and Anthonisen score and FEV1 percent of predictive were analyzed. The relation of lower respiratory tract infection and systemic inflammation was observed .Results :The value of serum CRP vary significantly in acute exacerbation of COPD patients, Its range is about 0.36-110mg/l ; CRP average (18. 26±10. 31) mg /L, is significantly higher than the healthy control group. Serum levels of CRP was positively correlated with Anthonisen score (r = 0. 409 , P < 0. 05). Patients whose FEV1% were above 70% of predictive had lower serum CRP level than those whose FEV1% were less 70 % of predictive ( P < 0. 01) ; Serum levels of CRP increased with the increasing degree of airflow limitation in patients whose FEV1% less than 70 % of predictive and was correlated positively with the degree of airflow limitation (r = 0. 707 , P < 0. 05) ;However, Differences among the groups was not significant (P >0. 05).Smear-positive rate increased with increasing degree of airflow limitation, the difference between the groups was statistically significant (P <0.05).Conclusion :Serum CRP level in patient s with acute exacerbations of COPD increased significantly and was correlated with Anthonisen score and the degree of airflow limitation. Serum CRP level might reflect the severity of acute exacerbations of COPD and might better than smear, WBC count, X-ray and other diagnostic method...
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