Plasma Copeptin,Procalcition Levels In Patients With Lower Respiratory Tract Infections And Their Clinical Significance

ObjectiveTo investigate the changes and clinical implications of plasma copeptin and Procalcition(PCT) levels in patients with lower respiratory tract infections(LRTI).MethodsA total of 45 LRTI,16 stable COPD patients and 14 healthy controls were enrolled.Their plasma levels of copeptin and PCT were measured by enzyme-linked immunosorbent assay(ELISA).CRUB-65 score were used to evaluate the severity of the patients with LRTI.Line correlation and spearman correlation analysis were used to analysis the correlations between plasma copeptin,PCT levels and body temperature, white blood cell,sedimentation rate,average hospital stay and severity score.ResultsCopeptin levels were significantly higher in patients with LRTI and COPD compared to controls.[(3.22±0.97)VS(0.74±0.22) ng/ml,(1.76±0.41)VS (0.74±0.22)ng/ml,P＜0.01]copeptin levels significantly higher in patients with AECOPD compared to COPD.[(3.14±0.98)VS(1.76±0.41) ng/ml,P＜0.01]PCT levels significantly higher in patients with LRTI compared to controls.[(2.28±1.56) VS(0.41±0.30)ng/ml,P＜0.01]By sputum culture results,the PCT levels in bacteria culture positive patients were significantly higher as compared to levels in negative. [(3.87±1.38) VS(1.72±1.03) ng/ml,P＜0.01],the plasma PCT levels were positively correlated with body temperature,white blood cell,sedimentation rate(r=0.40,0.34, 0.29,0.42.P＜0.05).The plasma copeptin and PCT levels were positively correlated with CRUB-65 score(r=0.631,0.425.P＜0.05)Conclusion 1.The plasma levels of copeptin and PCT were elevated in patients with LRTI. The copeptin levels were more closely correlated with severity score.2.Especially has bacterial infection,the plasma of PCT levels elevation significantly.To examine PCT maybe the assistant diagnosis index of infection.