The Relationships Study Of Transforming Growth Factor-β1 (TGF-β1) And Radiation-induced Lung Injury

Objectives To invest pre- or posttreatment plasma TGF-β1 levels and V20 associate with radiation-induced lung injury.Methods Fifty-three lung cancer patients who received 3DCRT,the tumor doses ranged between 40 and 70Gy, delivered in 2Gy/fractuion, 5 times/week. Control V20≤35% and dose of spinal cord≤45Gy. Apply ELISA to quantitate the concentration of pre- or posttreatment plasma TGF-β1 levels. Carry out clinical examination and CT of thoracic every one or two week. Adopted RTOG radiation scoring criteria to assess radiation-induced lung injury.Results The incidence of radiation injury was 35.7%(17/53),which 13.2% was Grade 2 or worse radiation-induced lung injury . When the post-TGF-β1 levels elevated, the incidence of lung injury was 51.9 % higher than the normal TGF-β1 levels(11.5%)(P=0.002), while it is increased or normal pre-TGF-β1 levels that has no correlation with radiation-induced lung injury(P=0.315). The radiation-induced lung injury development was 62.5% when V20>25% and post-TGF-β1 levels elevated ,especially higher than other groups .The patients whose V20≤25% and within normal post-TGF-β1 levels didn't develop radiation-induced lung injury.Conclusion The radiation-induced lung injury significantly related to the plasma TGF-β1 levels at the end of radiation. The patients are in the high risk whose V20>25% and post-TGF-β1 levels elevated .