Clinical Features And Associated Risk Factors Of 424 Patients With Nonalcoholic Fatty Liver

In recent years the non-alcoholic fatty liver disease mechanism studies have shown that insulin resistance in the formation of fatty liver plays an important role in the process. But WHO announced in 1999 the definition of the metabolic syndrome, as well as in 2002 the United States Cholesterol Education Program Adult Treatment Guide to the third group (NCEP-ATPIII), Fatty liver will not formally incorporated into areas of metabolic syndrome. Therefore, Study on the relationship between fatty liver and metabolic syndrome has also drawn more attention. In this paper, in 2007 our hospital medical center medical examination, 424 cases of non-alcoholic fatty liver and related risk factors were analyzed retrospectively, to be understanding through the study of non-alcoholic fatty liver disease and associated risk factors, evaluation of The relationship between fatty liver and metabolic syndrome, discussing the role of fatty liver in the metabolism syndrome pathogenesis, For the development of targeted prevention and treatment strategy to provide a scientific basis.Objective:1. In our hospital medical center, to analysis the medical cadres of non-alcoholic fatty liver prevalence and clinical features;2. To analysis selected patients with non-alcoholic fatty liver disease risk factors.3. To analysis selected patients with non-alcoholic fatty liver and metabolic syndrome and other clinical features.4. To explore the role of non-alcoholic fatty liver disease in the metabolic syndrome, in order to further work the relationship of the non-alcoholic fatty liver and insulin resistance, to provide the epidemiological evidence.Study object:In June 1-August 1 of 2007, to choose 424 cases of retired officers in our hospital medical center and undergoing a medical examination, among of them, 399 cases of male, 25 cases of female. Non-alcoholic fatty liver (NAFLD) 94 with a mean age of 69.98 years old, two cases of them women, were confirmed by the B-scan, with NAFLD diagnostic criteria [2]. Control group: To randomly select medical cadres of participating medical examination at the same time,and except fatty liver by diagnosis of B-scan, and age-matched for normal persons 276, the average age of 69.52 years, with 22 females with a mean age of 68.47 years old.Methods:Formulate a unified survey forms, including age, sex, diet, alcohol consumption, exercise and previous history; measurement of height, weight, systolic blood pressure, diastolic blood pressure, calculate body mass index (BMI), fasting blood test vein blood glucose (FBG), triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alanine amino-transferase (ALT), aspartic acid aminotr- ansferase (AST).Results:Of 94 cases of NAFLD group, male 92 cases (97.87%), with an average age of 69.98 years old 9.064. control group 276 cases, of which 270 cases of male (97.82%), with an average age of 11.92-69.52. Two groups of age, sex distribution similar.(1). NAFLD group mean arterial pressure, BMI, TC, TG control group (all p <0.05); NAFLD group HDL lower than the control group (P <0.05).(2). LDL no difference between the two groups was significant,in the ratio of hypertension and coronary heart disease (SBP≥140 mmHg and/or DBP≥90 mmHg and/or a previous history of hypertension) NAFLD group and the control group are similar (P> 0.05).(3). Of NAFLD group, 26 patients (27.6%) overweight, and 28 cases (29.79%) obese .of control group, 26 patients (9.4%), overweight, obesity 7 cases (2.5%).(4). NAFLD lipid profiles to high TG hyperlipidemia, high TC, high LDL and low HDL-c hyperlipidemia characterized.(5). The fasting plasma glucose of NAFLD group is higher than control group(P <0.05).Conclusion: The results show that the close relationship of the non-alcoholic fatty liver and metabolic syndrome based on insulin resistance in all relevant factors. NAFLD in elderly patients was higher than that of the general population, often abnormal liver function; obesity, type 2 diabetes, hyperlipidemia prevalence rate was significantly higher, the elderly NAFLD and insulin resistance, metabolic syndrome significantly related to obesity, hyperlipemia, diabetes in old age is a risk factor of older NAFLD, NAFLD is common cause of elevated serum transaminase in olders. Positive weight control, improve IR and the control of blood sugar, blood lipids adjustment disorder, the prevention and treatment of non-alcoholic fatty liver is great significance.