Production And Pharmocakinetic Research Of NCTD-proliposome

Norcantharidin(NCTD) is derivatived of cantharidin,it remained the most effective anticancer drugs against carcinoma hepatis,hepatocirrhosis,hepatitis cancer , esophageal carcinoma , gastric carcinoma , breast cancer , lung cancer.Contrast to cantharidin, NCTD has kept the advantages that it can promote the growth of leukocyte,and it is different from other anticancer drugs.However,the successful treatment with NCTD of conventional formulation remains difficult because of several pharmacokinetic and formulation factors that affect its disposition and toxicity,especially kidneys.The high concentration of NCTD is attributed to the presence of the renal damage.This experiment used ethanol inpouring method-lyopyilization to prepare NCTD proliposome. HPLC-UV method was established to determine the content of NCTD, and it had the better reproducibility and accuracy.In the research of ethanol inpouring method-lyopyilization,using the SAS software to optimize the prescription and preparation technology. The physico-chemical property and stability was also investigated. The studies on stability indicated that NCTD proliposomes should be stored at low temperature and against light,which ensured unchanged of their redispersity,encapsulation efficiency.Eventually, the pharmacokinetics research of NCTD in mice indicated that with regard to the NCTD solution,. The tissue distribution was increased in reticuloendothelial system. it has the obviously targetting.