The Relationship Between The Expression Of CXCR4 And MMP-3 And The Biological Characteristics Of Small Renal Cell Carcinoma

Objective: To explore the relationship between the expression of CXCR4 and MMP–3 and the biological characteristics of small renal cell carcinomaMethods:We compared the clinical data of 66 cases with small renal cell carcinoma (D≤4 cm) and 96 cases with large renal cell carcinoma( D>4 cm) in 162 renal cell carcinoma cases from June 1999 to December 2006 . The expression of MMP-3 , CXCR4 were studied by means of immunohistochemistry (SABC) in 30 small RCC , 30 large RCC and 20 normal renal tissue .Results:The small RCC has lower clinical stage and the two group have significant difference (P < 0.05) . The 3-year survival rate was 100 % and 70.5%( P < 0. 05) , 5-year survival rate was88.2 % and 54.5 % (P < 0.05) respectively in the two groups.The expressions of MMP-3 and CXCR4 in RCC are significantly different than those in normal renal tissue (P < 0.01) . There is significant difference in the expressions of MMP-3 and CXCR4 between small and large RCC (P < 0.05). The expressions of MMP-3 in small RCC are significant higher than those in normal renal tissue (P < 0. 05). And there is no significant difference in the expressions of CXCR4 between small RCC and normal renal tissue (P>0.05) . The expressions of MMP-3 and CXCR4 in RCC is positively related.Conclusions :The small RCC has lower clinical stage , better prognosis and higher survival rate. The biological behaviour of small RCC is less malignant,the possibility of invasion and metastasis of small RCC is less than its of large RCC . The different expressions of MMP-3 and CXCR4 may play an important role in pathogenesis of renal cell cancer, and they may be valuable for predicting prognosis of renal cell cancer.