| The technology of pharmaceutical analysis and inspection takes an important rolein pharmaceutical investigation,so studied and founded the sensitive and quick analysismethod is important for the new drugs exploitation,pharmacological studying and theclinic application.The development and application of ion-selective electrodes continueto be of interest for pharmaceutical analysis because these sensors offer the advantagesof simple design and operation,reasonable selectivity,fast response,low cost,broadconcentration range and applicability to turbid and colored solutions.This thesisexplored producing an new ion-selective electrode and established an new electrochemical analysis method on venlafaxine hydrochloride,granisetron hydrochloride or epinastine hydrochloride.Partâ… Study of an ion-selective electrode of venlafaxine hydrochlorideA novel venlafaxine hydrochloride ion membrane electrode is prepared,characterized and used in pharmaceutical analysis.An electrode system withvenlafaxine-tetraphenylboron is selected as the electroactive material,o-NPOE as theplasticizer.The electrode exhibits a fast near-Nernstian response for 1.0×10-1～8.0×10-6 mol·L-1 venlafaxine with the slope of 58.6 mV/decade.The minimal detectionlimit is 5.2×10-6 mol·L-1.The electrode is stable and reproducible and can be used forpotentiometric determination of venlafaxine hydrochloride capsules directly.Therecovery range is 98%～101%.The results agree with those determined ofpotentiometric titration.Partâ…¡Study of a granisetron hydrochloride selective electrodeA new granisetron hydrochloride selective electrode based on granisetron-tetraphenylboron as a carrier is prepared,which exhibits a fast near-Nernstian response for 5.0×10-2～1.0×10-5 mol·L-1 granisetron with the slope of 58.7 mV/decade.Theminimal detection limit is 8.0×10-6 mol·L-1.The electrode is stable and reproducible and can be used for potentiometric determination of granisetron hydrochloride tablets directly.The recovery range is 99%～102%.The results agree with those determined ofHPLC.Partâ…¢Study of an epinastine hydrochloride selective electrodeA new epinastine hydrochloride selective electrode based on epinastine-tetraphenylboron as a carrier is prepared,which exhibits a fast near-Nernstian response for 1.0×10-2～5.0×10-6 mol·L-1 epinastine with the slope of 59.9 mV/decade.Theminimal detection limit is 3.0×10-6 mol·L-1.The electrode is stable and reproducible and can be used for potentiometric determination of epinastine hydrochloride tablets directly.The recovery range is 98%～101%.The results agree with those determined of HPLC.Partâ…£Study of Ion-selective Electrode Based on PVC Membrane Coated-wirevenlafaxine hydrochloride and granisetron hydrochloride ion-selective electrodesbased on PVC membrane coated-wire were prepared,which exhibit a fastnear-Nernstian response for 1.0×10-2～5.0×10-5 mol·L-1 venlafaxine and granisetronwith the slope of 57.0 and 56.5 mV/decade.The minimal detection limit is 2.0×10-5 and 2.3×10-5 mol·L-1.The electrodes can be used for potentiometric determination ofvenlafaxine hydrochloride capsules and granisetron hydrochloride tablets directly.Theresults agree with those determined of potentiometric titration or HPLC.
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