Study On Chemotherapy-Induced Glucose Metabolic Disorders In Patients With Mammary Gland Cancer

Objective: To determine the infuence of chemotherapy on glucose metabolism in patients with mammary gland cancer. Methods: We selected 250 female mammary gland cancer cases accepted postoperative adjuvant chemotherapy of paclitaxel and vinorelbine from January 2005 to December 2006 and analyzed the cases retrospectively, according to the blood glucose assay and associated clinical materials before and after chemotherapy. Results: The blood glucose after chemotherapy was more increasing than that before chemotherapy (P<0.05).Fouty-two (16.8%) cases had elevated fasting blood glucose level after chemotherapy .Among them ,9 cases (3.6%) were diagnosed as diabetes mellitus.Paclitaxel based chemotherapy and vinorelbine based chemotherapy were the same in menopause,cardiovascular disease,age and body mass index(P>0.05). Paclitaxel based chemotherapy did not seem to have more opportunity to induce the incidence of diabetes mellitus than that vinorelbine based chemotherapy(P>0.05).The two chemotherapy both could elevate fasting blood glucose level of the patients,but there were not different(P>0.05).Conclusion: Chemotherapy induced disorders of glucose metabolism,even diabetes mellitus,but paclitaxel based chemotherapy did not seem to have more opportunity to induce the incidence of diabetes mellitus than that vinorelbine based chemotherapy.