Clinical Observation Of Regional Chemotherapy On Breast Cancer Patients With Sustained-release Fluorouracil For Implant During Operation

Objective: To investigate the safety and therapeutic effects of regional chemotherapy by using fluorouracil Sustained-release implants during the breast cancer operation. Methods: By using the randomied contrzol method, we set the patients who had been attended on Monday and Wednesday into the control group (n=26), the patients on Tuesday and Thursday into the implanting group (n=28).The fluorouracil Sustained-release implants had been implanted in the implanting group. Post-operative toxic and side-effects, disease-free survival rate (DFSR) and the overall survival rate (OSR) had been compared between the two groups. Results: The Difference of the clinical manifestations (nausea, vomiting, alopecia), the result of laboratorial examinations (Blood routine test, liver and renal function,) and Surgical incision healing between two groups were not significant (P>0.05). The 3-12 months disease-free survival and the overall survival rates for both two groups showed no statistical significance (P>0.05). Conclusions: The drug toxicity, DFSR and OSR between two groups showed no statistical significance. We concluded that the regional chemotherapy by using fluorouracil sustained-release implants during the breast cancer operation is safe, but further follow-up will be needed to determine whether it can prevent the local tumor recurrence and metastasis, meanwhile to improve the DFSR, OSR.