| Objective To investigate the different manifestations and clinical value of hydrogen proton magnetic resonance spectroscopy in brain tumor.Methods 36 patients with surgical biopsy and clinical follow-up diagnosis of brain tumor were examed by GE signa 1.5T ExciteⅡMR superconducting scanner(22 patients with glioma,metastatic tumors in 11 cases,3 cases of lymphoma).Examing sequences contained conventional MRI scans including Axial TlWI,T2WI,T2FLAIR,DWI and sagittal T2WI and after intravenous injection of Gd-DTPA(Gd-DTPA,0.2mmol/kg),axial,sagittal and coronal T1WI examed. After setting up the largest level in the tumor(including enhanced part,peritumoral edema. corresponding contralateral normal brain parenchyma) to be areas of interest in hydrogen proton spectroscopy scanning,then analyze the collected spectral data using Function Tool software in the areas of enhanced tumor tissue,high signal area on T2WI and corresponding contralateral normal area.The data contains major metabolites peaks.The major metabolites are N-acetylaspartate(NAA),Choline-containing compounds(Cho ), Creatine and phosphocreatine(Cr).Then Cho/Cr,NAA/Cho,NAA/Cr were calculated.Result The Cho/Cr,NAA/Cho,NAA/Cr values of strengthened and edema area of glioma were 3.1811±2.3135,0.4144±0.2818,1.0485±0.7123;2.0879±1.5921,0.727±0.5272,1.2169±0.7079.The Cho / Cr,NAA / Cho,NAA / Cr values of the strengthened and edema of metastases were 3.2104±1.3423,0.6352±0.2086,1.3111±0.4946;1.3313±0.4254,1.1463±0.3303,1.7677±0.7002.Corresponding contralateral normal brain tissue as a reference group,Cho / Cr,NAA / Cho,NAA / Cr values were significant differences(P＜0.05) between abnormal strengthened and edema area of glioma and corresponding contralateral normal area;Cho/Cr,NAA/Cho,NAA/Cr values were significant differences(P＜0.05) between strengthened area of Metastases and the corresponding contralateral normal area.Cho / Cr,NAA / Cho,NAA / Cr was no significant difference between peritumoral edema district of metastases and the corresponding contralateral normal area.Comparing abnormal strengthened area with edema area,Cho/Cr,NAA/Cho,NAA/Cr values were not statistically different in glioma. Cho/Cr,NAA/Cho values have significant difference(P＜0.05)between strengthened and peritumoral edema Regions of metastases;The NAA/Cr was no significant difference. Comparing the abnormal strengthened of glioma with metastatic tumors,the Cho/Cr, NAA/Cho,NAA/Cr were no significant difference;The edema region of both,Cho / Cr was no significant difference,and NAA / Cho,NAA / Cr values are statistically significant differences(P＜0.05).Conclusion Multi-voxel ~1HMRS examination has important clinical value in brain tumor diagnosis and differential diagnosises.
|
PDF Full Text Request