Expressions And Clinicopathologic Significance Of ERβ, C-erbB-2, COX-2 In Human Breast Carcinoma

Objective:To investigate the expressions of ERα,ERβ, C-erbB-2 and COX-2 in breast invasive ductal carcinoma and to explore its correlations with the clinicopathological factors and prognosis,and to study the relationship between ERβ,C-erbB-2 and endocrine therapy resistance. Methods:ERα,ERβ,C-erbB-2 and COX-2 were detected by S-P immunohistochemical technique in 86 cases of breast invasive ductal carcinoma.The data was analyzed combining with clinicolpathological character and prognosis usingχ2 test, Kaplan-Meier method and Cox model. Results:(1)The expression of ERβwas significantly correlated with lymph node metastasis,clinical stage(P<0.05),and no significant correlation with age ,tumor size,menopause or not and pathological grading(P>0.05);The expression of C-erbB-2 was significantly correlated with tumor size and lymph node metastasis(P<0.05), and no significant correlation with age , clinical stage,menopause or not and pathological grading(P>0.05);The expression of COX-2 was significantly correlated with tumor size,clinical stage,pathological grading(P<0.05),and no significant correlation with age , lymph node metastasis and menopause or not(P>0.05).(2) For ERβnegative group, the 5-year overrall survival (OS)and disease free survival(DSF) rate in endocrine therapy group were 87.29%,84.06% respectively superior to those in non-endocrine therapy group (53.87%and53.87%) (P<0.05),while for ERβpositive group,the 5-year OS and DFS rate in endocrine therapy group and those in non-endocrine therapy group were no significant difference (P>0.05). (3) ERα, ERβ,C-erbB-2 and lymph node metastasis were important influence factors for the patient survial time in Cox multivariant analysis. Conclusion:(1)The expressions of ERβ,C-erbB-2 and COX-2 may play crucial roles in the carcinogenesis and development of breast invasive ductal carcinoma .(2)Endocrine therapy is effective in ERβnegative breast cancer patients . Detecting the expressions of ERα,ERβand C-erbB-2 is significance in determing the effect of endocrine therapy for breast invasive ductal carcinoma.(3)ERα,ERβ,C-erbB-2 and lymph node metastasis were the relatively factors for breast cancer patient's postsurgercal survival time.