| Objective: Analysis of 30 patients with temporal lobe epilepsy patients with clinical manifestations and changes in cardiovascular function, simultaneous determination of the norepinephrine, dopamine, 5 - HT level. Further confirmed monoamine neurotransmitter patients with temporal lobe epilepsy caused by the closely related to cardiovascular function. Explore temporal lobe epilepsy with changes in cardiovascular function mechanism for the clinical effective intervention to prevent the occurrence of cardiovascular events, and to improve the prognosis of the patients and provide a theoretical basis.Methods: According to ILAE 1981 and 1989 respectively by seizures and epilepsy syndrome classification, based on seizures, epilepsy and head of clinical MRI and EEG findings selected 30 cases of patients with temporal lobe epilepsy and 30 cases Non-patients with temporal lobe epilepsy. According to the epilepsy clinical manifestations and MRI and EEG findings selected patients with temporal lobe epilepsy. ECG analysis of its performance, myocardial enzyme changes, and changes in renal function observed. At the same time detection using fluorescent spectrophotometry goal of plasma norepinephrine, dopamine, 5-HT level and the changes in comparison with the control group, for statistical analysis.Results:1. Patients with temporal lobe epilepsy clinical manifestations 30 cases of patients with temporal lobe epilepsy attack from local start-up, complex partial seizure. Attack Threatened in spirit, eyes, limbs, speech, and other aspects of performance. Spirit could have consciously fever, fear, irritability, heart before the District hard, hard-conscious side of the body; Eye performance eyes straight, stop action and speech, such as eye gaze to the side. Speech has to scream, smack one's lips, angulus oris tic, speech disorders. Physical movements have side limbs tremble, both physically jitter, indiscriminate taking gropers to find things, not with the soles of the feet, standing instability. There are other aspects of headache, hypsokinesis of head, palpitation, throat spasm, such as tinnitus with see something unclear. Attack manifested as loss of consciousness, the call should not be physically tension increased, or mechanical action repeat, such as migration, exploration, as well as running himself, with trismus, even with tongue bitten or urine incontinence. Average duration (11±4.5) minutes. After the attack could be accompanied by dim awareness of the state.2. temporal lobe epilepsy patients with ECG, 30 cases of myocardial enzyme content in patients with temporal lobe epilepsy are done ECG, including 18 patients found that a change in electrocardiogram, accounting for 60 percent. Abnormal electrocardiogram showed major changes in heart rate, arrhythmia (including shortening the period between PR with atrioventricular block two cases, accounting for 7 percent; sinus rhythm missing three cases, accounting for 10 percent, sinus tachycardia four cases, 13 per cent, sinus bradycardia three cases, accounting for 10%); T-wave inversion Diping four cases (13%), sT elevation or downward movement of two cases (7%).In addition to the detection of myocardial enzyme we know: 30 patients with temporal lobe epilepsy patients, 15 patients with elevated creatine kinase, accounting for 50 percent; 16 patients with temporal lobe epilepsy LDH increased, accounting for 53.33 percent; 11 patients with temporal lobe epilepsy aspartate aminotransferase increased, accounting for 36.67 percent. Serum of patients with temporal lobe epilepsy creatine kinase, lactate dehydrogenase than non-patients with temporal lobe epilepsy, P <0.01, a significant difference in patients with temporal lobe epilepsy aspartate and non-temporal lobe epilepsy patients showed no statistically Difference. Non-temporal lobe epilepsy patients with creatine kinase, lactate dehydrogenase, aspartate transferase and the normal control group, P> 0.05, there was no statistical difference. Tip temporal lobe epilepsy patients with cardiovascular changes.3. Temporal lobe epilepsy patients monoamines changeThrough the plasma norepinephrine, dopamine, 5 - serotonin testing, we concluded: temporal lobe epilepsy patients between the onset of plasma norepinephrine, 5 - serotonin levels higher than that of non-temporal lobe epilepsy group And the control group (P <0.01), a significant difference between non-patients with temporal lobe epilepsy to a adrenal gland, 5 - serotonin than normal control group (P <0.01), a significant difference. Patients with temporal lobe epilepsy dopamine lower than the control group (P <0.01), a significant difference between non-temporal lobe epilepsy group compared with the normal plasma dopamine reduced (P <0.01), a significant differenceConclusion: 1. Temporal lobe epilepsy patients with ECG changes, including arrhythmia, and ST segment depression, T-wave downward. Arrhythmia include sinus arrhythmia, sinus rhythm slow, sinus rhythm too fast, and P-R shorten the interval with AVB.2. Patients with temporal lobe epilepsy creatine kinase, lactate dehydrogenase, aspartate aminotransferase enzyme and lactic dehydrogenase isoenzymes were higher. One temporal lobe epilepsy patients with creatine kinase, LDH, lactate dehydrogenase isoenzymes than a non-temporal lobe epilepsy patients with high, a significant difference. Temporal lobe epilepsy patients with aspartate aminotransferase and non-patients with temporal lobe epilepsy, no difference, P> 0.05. Which patients with temporal lobe epilepsy serum creatine kinase, LDH, lactate dehydrogenase isoenzymes 1 and serum of patients with non-temporal lobe epilepsy compared to a statistical difference.3. patients with temporal lobe epilepsy norepinephrine, 5 - HT level higher than that of non-temporal lobe epilepsy patients and normal subjects (P<0.01), dopamine was lower than that of non-temporal lobe epilepsy and normal(P<0.05 and P<0.01), suggesting that patients with temporal lobe epilepsy changes in the cardiovascular activities And is closely related to neurotransmitters.Comprehensive, temporal lobe epilepsy patients with complex clinical manifestations, and its main clinical performance to decline with a clear sense of mechanical repetition actions, such as migration, exploring, running and talking to himself, before the onset seizures threatened. In observation of the 30 cases in patients with temporal lobe epilepsy in 18 cases of ECG changes, including sinus rhythm missing, sinus tachycardia, sinus bradycardia, PR shorten the interval with atrioventricular block, ST Paragraph down, T-Diping, while changes in the level of myocardial enzyme exists. Through the detection of monoamine neurotransmitters, confirmed that patients with temporal lobe epilepsy norepinephrine, 5 - serotonin than non-temporal lobe epilepsy patients with normal people. Tip temporal lobe epilepsy patients with cardiovascular changes, and this change and consider Neurotransmitter changes are closely related.
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