| Primary biliary cirrhosis (PBC) is a kind of disease of chrinic intrahepatic cholestasis, It appearances as progressive apyetous des- tructive inflammation of small intrahepatic bile ducts in pathology. With the further development of hepatic fibrosis and hepatic cirrhosis; It is characterized by female predominance with most cases observed between the ages of middle age and gerontism, the incidence is about 1%～2% in the Chinese hepatic disease, with the still unknown etiological factor and pathogenesy, there is still no effective method to cure it at present. studies indicate the treatment of ursodeoxycholic acid at early days can prominent delay the proceeding of the disease, improve prognosis, the specific antibody of anti-mitochondrial antibody(AMA), anti-M2(AMA-M2) have highly sensitive and specificness, the latter can utendus early diagnosis, non-vulnerarious diagnosis.Because of the further known of PBC and the occurrence of various kinds of immunologic test facility, the morbility of PBC has a higher tendency, so it has a great significance to strengthening the screen in the high-risk group, Early diagnosis, earty treatment.ObjectiveAnalyze the predilection sexuality, ages, cardinal symptom, ob- -jective sign, biochemical representation, immunologic representation of PBC, Especially the positive rate of AMA and AMA-M2, Whether there are dependablities between antibody titre and the degree of injury of liver or not, analyze the masculine rate of antinuclear antibody and other immunal index.Materials and methodsThirty-eight patients who were diagnosed as PBC is slected from NO.1 hospital of jilin university between January 2000 and January 2008. calculating age, sexuality, clinical manifestation, et al, deteced liver fuction, blood fat, blood dedimentation, ANA and The grouping, autoantibody, AMA-M2, imageology examination identificated both inter hepatic bile duct and extrahepatic bile duct were normal, besides there were no virology evidence.Results94.74% of the patients are female, with the average age of 53.84±10.90, the incidence of the most common symptom in order are as follows: debility for 81.58%, jaundice for 60.53%, titillationfor 50%, poor appetite for 47.37%, abdominal distention for 44.74%, the incidence of the most common objective sign in order are as follows: splenomegaly for 34.21%, abdominal dropsy for 23.68%, liver palm for 21.05%, spider telangiectasia for 18.42%, hepar auctum for 15.79%, the liver function: 94.74% of the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are higher than normal, 92.11% of theγ-glutamyltransferase, 89.47% of the alkaline phosphatase 68.42% of the total bilirubin / direct bilirubin, 65.79% of the total bile acid are higher than normal, too. eighteen of the patients were detected the blood fat, nine of them with a higher cholesterol,at the rate of 50%, three of them with a higher triglyeride, at the rate of 16.67%, thirty of the patients were detected the urine bilirubin and sixteen of them were positive, at the rate of 53.33%, twenty of the patients were detected the blood clotting and eleven of them had a longer activeted partial thromboplastin time (APTT), at the rate of 47.83%, twenty-one of the patients were detected the AMA and fourteen of them were positive, at the rate of 66.67%, thirth-three of the patients were detected the AMA-M2 and nineteen of them were positive,at the rate of 59.38%, thirty-two of the patients were detected the ANA and all of them had a positive result, so the rate is 100%, nineteen of the patients were detected the anti-gastric parietal cell antibody (GPC) and eight of them were positive, so the rate is 42.11%, nineteen of the patients were detected the anti-liver kidney microsomal antibody (LKM) and five of them were positive, so the rate is 26.32%, nineteen of the patients were detected the anti- antismooth muscle antibody (SMA) and two of them were positive ,so the rate is 10.53%,among the patients with M2 positive, (+) 52.63%, (++) 36.84%, (+++) 10.53%, among the patients with ANA positive, thirty of then had the potency of 1:320, only two patients had the potency of 1:1000, of the total, the type of caryotheca had a positive number of 11, about 34.38% among all the patients with positive ANA, the type of anti-chondrio-some had a positive number of 5, about 15.62% among all the patients with positive ANA, thirteen of the patients were detected the protein electrophoresis, nine of them with a higherγ-globulin, at the rate of 69.23%, twenty-five of the patients were detected the immune globulin, seventeen of them with a higher immunoglobulin M, at the rate of 68%, fourteen of them with a higher immunoglobulin G, at the rate of 56%, twelve of the patients were detected the Blood sedimentation, eleven of them were higher than normal, at the rate of 91.67%, the liver function of the patients had no significant difference among the different titre of M2.ConclusionThis group of patients diagnosed as PBC had a lower AMA and M2 positive rate than both internal and abroad, we can't identificate there are connection between the patients with different liver function and different titre of M2(p〈0.05), the detection of ANA has considerable significance, but not the specific immunal examination, The exploring of new target, the conjoind detecting of different approach, different antigenic component, different subgroup will be more predominant for the early diagnosis and non-vulnerarious diagnosis.
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