| Human chorionic gonadotropin(HCG) is a glycoprotein hormone secreted by the placenta syncytiotrophoblast cells during pregnancy, but have little in the non-pregnant circumstances, Only sperm cells and fetal tissue have some very low level of HCG. HCG is composed ofαsubunit andβsubunit. HCG and its interaction with the receptor caused mainly depends on the biological effects ofβsubunit ,βsubunit of human chorionic gonadotropin can stimulate the growth of cancer cells specific. Some scholars believe that HCG is a autocrine factor for the tumor , have a growth factor-like role,and closely related to the growth of malignant self-regulation function, the transfer features and tumor differentiation, as well as tumor micro-environment and the formation of immune tolerance.There are more forms of the presence of HCG in body, including HCG, HCG nicked, HCGαsubunit, HCGβsubunit, HCGβsubunit core fragment and high glycosylation of HCG. Many non-trophoblast cells from malignant tumors can be produced and secreted HCG. Ovarian cancer is currently the highest mortality gynecologic malignancies, and most studies have found that ovarian cancer can also ectopic expression HCG.βHCG gene expression was also considered one of the characteristics of ovarian cancer.This study will research the characteristics ofβHCG in ovarian cancer tissue, Discussion the relationship between Ectopic of HCG and ovarian cancer tissue type, degree of differentiation, To reveal Relations of HCG and the development and prognosis of ovarian cancer.The 26 cases ovarian cancer resected specimen come from the second Jilin University Hospital of Obstetrics and Gynecology during November 2006 to 2007 November. Ages from 17 to 68 years old, The average 51.2-year-old. Histological types: 21 cases of epithelial ovarian tumors (Serous cystadenocarcinoma), 4 cases of Ovarian germ cell tumors(Immature malignant teratoma) and 1 cases of metastatic ovarian tumor(Krukenberg tumor); Differentiation: 13 patients with poorly differentiated carcinoma; Moderately differentiated carcinoma seven cases and six cases of well-differentiated carcinoma. 15 cases with benign ovarian cancer, Ages from 20 to 62 years old, The average 37.2-year-old. 3 cases of ovarian cyst,2 cases of serous cystadenoma,4 cases of mature teratoma,3 cases of theca cell tumor,1 case of fibroma and 2 cases of ovarian endometriosis . Two cases of pregnancy of 60 days placental villi organizations as a positive control and 10 cases of normal ovarian tissue as a negative control. Using immunohistoch- emistry detected in the expression ofβHCG in specimen.The results showed that benign ovarian cancer tissue expression withoutβHCG. The 26 cases of malignant tumors, 11 patients withβHCG expression, the positive rate was 42.3%. See from the histological types, 11 cases were positive tumors of epithelial ovarian tumors--Serous cystadeno carcino- ma;See from the differentiation, one case well-differentiated carcinoma were positive, the positive rate was 16.7%, shallow staining positive granules; Moderately differentiated carcinoma three cases positive, the positive rate was 42.9%; positive granules stained deep in well-differentiated carcinoma; Seven cases were poorly differentiated carcinoma, the positive rate was 53.8%; positive particles were obviously deeply in well-differentiated cancer and Moderately differentiated cancer.Benign ovarian cancer tissue expression withoutβHCG and some of ovarian cancer can express HCG. Epithelial ovarian cancer are much more likely to ectopic expression HCG, HCG through increased insulin-like growth factor-1 (IGF-1), thereby stimulating ovarian surface epithelium (OSE) proliferation and anti-apoptotic. Under physiological conditions escape apoptosis is considered an important start the process of tumor, HCG can anti-apoptotic of OSE, So HCG sustained cyclical role in ovarian may be induced by the occurrence of ovarian cancer.βHCG in different degree of differentiation of cancer cells expressed different degrees, With the following possible reasons:1. Tumor cells synthesis and secretionβ-HCG, The molecule can play the role in the tumor cells by autocrine and(or) Paracrine and promote the tumor growth;2. HCG can inhibit the body cells of the tumor antigen immune response and humoral immune response, HCG molecules of cell surface can inhibit the activity of T lymphocytes;3. HCG positive tumor cells are highly invasive. We come to the following conclusions: 1. Epithelial ovarian cancer are much more likely to ectopic expression HCG; 2. The expression ofβHCG in cancer cells have significantly heterogeneity, differentiation of the tumor cells, the lower the easier it is to expressβHCG, which is the expression of the more;3.Ectopic HCG will be a new tumor marker which will help identify tumor between cancer and estimate the state of the illness after treating.
|
PDF Full Text Request