Effects Of The Amino Acids Parenteral Nutrition On The Nutritional Status And The Immune Function Of The Non-Small Cell Lung Cancer Patients Receiving Chemotherapy

Objective Prospective clinical research was carried out by using the amino acid parenteral nutrition (PN),to the non-small cell lung cancer (NSCLC) patients during the three cycles of chemotherapy. We want to analyse the dynamically effects of the amino acids support including the nutritional status and the immune function of the NSCLC Patients. We also want to make clear the preventive and therapeutic effects of Co-AA on cisplatin nephrotoxicity of NSCLC. Experimental support will be provided by these datum to the tumor patients.Methods Sixty NSCLC patients ready to receive chemotherapy were randomly assigned to two groups. Each group received three cycles of chemotherapy of 21 days with conventional diuretic hydration. The 29 cases in the treated group were given Co-AA by vein once a day, 500ml every time for 8 successive days while the other 31 cases in the control group were treated by chemotherapy alone. The changed condition of nutritional status, immune function and damaged nephrons were monitored dynamically and compared at different time points by measuring the MNA (Mini-Nutritional Assessment ), ALB (albumin), PA(prealbumin), LC(lymphocyte count) and BMI (body mass index); T cell subpopulations, IgG (immunoglobulin G) and IgM(immunoglobulin M); BUN (blood urea nitrogen), sCR (serum creatinine), cCr (creatinine clearance), uSG(urine specific gravity) and uPH (urine power of hydrogen) .Resultsâ‘ The levels of MNA, ALB and PA fallen to the valley value on the third chemotherapy cycle in each group (p <0.01). However, comparison between the two groups showed that the MNA ,ALB and PA in the treated group on the second and third chemotherapy were higer than the parameters at the corresponding time points in the control group (p <0.01).â‘¡The percents of CD3+, CD4+, NK cell , IgG, IgM fallen to the valley value on the third chemotherapy cycle in each group (p <0.05),while the percent of CD8+ cell reached the peak on the third chemotherapy cycle in each group (p <0.01); However, comparison between the two groups showed that the percent of CD4+ and NK cell, IgG, IgM in the treated group on the second and third chemotherapy were higer than the parameters at the corresponding time points in the control group (P<0.05), while the contrary was observed in CD8+.â‘¢The levels of BUN, sCr, uSG reached the peak on the 65th day in both groups they came up gradually. However, comparison between the two groups showed that only the cCr and uSG in the treated group on on the second and third chemotherapy were higer than the parameters at the corresponding time points in the control group (p <0.01), while the contrary was observed in the uSG(p <0.01).Conclusion:â‘ The effect of nutritional status in NSCLC patients who received chemotherapy is regular in time, and reversible when treated suitably. Co-AA shows a marked effect in nutritional status.â‘¡The effect of chemotherapy on the immune function in NSCLC patients is regular in time, and reversible when treated suitably. Co-AA shows a marked effect in the immune function..â‘¢The damage of chemotherapy with DDP on nephron is also regular in time, and reversible when treated suitably. Co-AA shows a marked effect in protecting and treating the damage on nephron caused by DDP.