Effect Of Early Immune-enhanced Enteral Nutritional Support On Postoperative Immune Function In Elderly Patients With Colorectal Cancer

Objective: To explore the effect of early immune-enhanced enteral nutritional support on postoperative immune function and nutritional status of elderly patients with colorectal cancer.Methods:Select 75 elderly patients with colorectal cancer in our hospital,randomly divided into 3 groups:early immune-enhanced enteral nutrition support group(EIEN,25cases),early standard enteral nutrition support group(EEN,25cases),and delayed enteral nutrition support group(DEN,25cases),post-operative nutrition support,.peripheral venous blood samples were taken in the three groups from the morning before the first day,the first day after the operation,and the seventh day after the operation.Immune function indicators T lymphocyte subsets(CD3,CD4,CD8,CD4/CD8),immunoglobulins(Ig A,Ig M,Ig G),And nutrition indicators [total protein(TP),prealbumin(PA),albumin(ALB),transferrin(TF)],and comparative analysis of various indicators.Results:(1)Comparison results of cellular immune indexes There was no significant difference in the levels of cellular immune indexes CD3,CD4,CD8 and CD4/CD8 between the EIEN group,EEN group and DEN group 1 day before operation and 1 day after operation,and there was no statistically significant difference between the groups(P>0.05),After postoperative nutritional support,the CD3 and CD4 of the patients in the EIEN group were higher than those in the EEN group on the 7th postoperative day(P<0.05).The CD3,CD4 and CD4/CD8 of EIEN group were significantly higher than those of DEN group on the 7th day after operation,and the differences were statistically significant(P<0.01),while CD8 wassignificantly lower than that of DEN group,the difference was statistically significant(P<0.01).(2)Humoral immune index comparison results There was no significant difference in Ig A,Ig M and Ig G indexes between EIEN group,EEN group and DEN group 1 day before operation and 1 day after operation,and there was no statistically significant difference in various immunoglobulin indexes(P>0.05).After postoperative nutritional support,the Ig A and Ig G of the patients in the EIEN group were higher than those in the EEN group on the 7th postoperative day(P<0.05).The Ig A,Ig M and Ig G of the patients in the EIEN group were significantly higher than those in the DEN group on the 7th postoperative day(P<0.01).(3)Comparison result of nutrition index There were no significant differences in TP,PA,ALB,TF indexes between EIEN group,EEN group and DEN group 1 day before operation and 1day after operation,and there was no statistically significant difference in the comparison of each index(P>0.05).After postoperative nutritional support,the TP,PA,and ALB of the patients in the EIEN group were higher than those of the EEN group on the 7th postoperative day(P<0.05).Although the TF was higher than that of the EEN group,there was no statistical difference.Academic significance(P>0.05).The TP,PA,ALB,and TF indexes of patients in the EIEN group were significantly higher than those in the DEN group on the 7th postoperative day(P<0.01).Conclusion:Elderly colorectal cancer patients undergoing early immune-enhanced enteral nutritional support have better effects on improving the patient's postoperative cellular immunity,humoral immune level and nutritional status,and can be used as a postoperative nutritional support method for colorectal cancer patients at this stage.