Clinical Research After Wavefront-guided Combining Q-value Guided Optimized Aspheric Transition Zone LASIK

AimLaser in situ keratomileusis has become the main stream of photorefractive keratectomy for its good accuracy,safety,efficacy.LASIK satisfied most of patients who has refractive problems, but conventional laser in situ keratomileusis makes superficial shape of cornea changed(make the shape prolate)and that makes high order aberrations(spherical aberrations)increased during the operation of laser in situ keratomileusis,which will effect patients' visual quality.In order to decrease patients' high order aberrations,two methods of LASIK operations were proposed in recent years,which are wavefront-guided and Q-value guided optimized aspheric transition zone LASIK.The aim of wavefront-guided LASIK is to eliminate the high order aberrations at preoperation,the aim of optimized aspheric transition zone LASIK is to decrease the high order aberrations at postoperation.Wavefront-guided combining Q-value guided optimized aspheric transition zone LASIK not only decrease high order aberrations at preoperation but also at postoperation,and it can increase patients' visual quality.In our study we discuss the therapeutic effect of wavefront-guided combining Q-value guided optimized aspheric transition zone laser in situ keratomileusis in treatment of low and moderate myopia.Methods1.In a prospective study 158 low and moderate myopia patients' right eyes were involved,and the patients had a period of 6 months after LASIK in Shengjing hospital at 2006.12 to 2007.11.The myopia degree≤-6.00 D,the astigmatism degree＜-3.00 D, the range of age was 18～35,best corrected visual acuity≥1.0,the depth of cornea≥500μm and root mean square(RMS)of high order aberrations≥0.30μm when the diameter of pupil in dark adaptation is 6.00 mm.40 eyes were treated with wavefront combined aspheric profile LASIK in group A,and 38 eyes were treated with aspheric profile LASIK in group B,39 eyes were treated with wavefront LASIK in group C,41 eyes were treated with standard LASIK in group D.The preoperative and postoperative wavefronted aberrations value,visual acuity,best corrected visual acuity and refraction of all eyes were noted,this study has received the agreement of all patients.2.Measure the high order aberrations of the four group patients before and after operations using WASCA Analyzer made by the Zeiss company in Germany.3.F test and t test were used to analyse the difference of high order aberrations,USCVA,BSCVA and refraction at preoperation 1,3,6 month after operation between four groups.P＜0.05 was considered statistically significant.Results1.All of operations on 158 cases were successful without severe complication after 6 months' follow-up.2.Wavefront-guided combining Q-value guided optimized aspheric transition zone laser in situ keratomileusis has satisfied accuracy,safety,efficacy in accord with other three groups.There are no significant difference between four groups(P＞0.05).3.The values of total higher order aberrations and spherical aberrations in group of wavefront-guided combining Q-value guided optimized aspheric transition zone laser in situ keratomileusis were significantly smaller compared to other three groups.Conclusion1.Wavefront-guided combining Q-value guided optimized aspheric transition zone LASIK has perfect accuracy,safety,efficacy.2.Wavefront-guided combining Q-value guided optimized aspheric transition zone LASIK is a more effective procedure to improve subjective visual sensation and decrease higher order aberrations compared to standard LASIK or wavefron-guided LASIK or aspheric profile LASIK.