Study Of The High Risks Of The Coronary Artery Lesion In Kawasaki Disease

Objective:To investigate the correlation among the clinical records and Insertion/Deletion polymorphism of ACE (angiotensin converting enzyme), the onset of KD and the complicating CAL(coronary artery lesion).Method:1. According to the Kobayashi score and national researches , we selected 10 clinical records including day of illness at initial treatment, age in months, percentage of white blood cells representing neutrophil, platelet count, serum aspartate aminotransferase, sodium, C-reactive protein, hemoglobin, male, the duration of the fever as the high risks of the coronary artery lesion in KD and analyzed these in 137 children affected by KD of which there were 17 patients with CAL.2. Insertion/Deletion polymorphism of ACE was detected by PCR( Polymerase Chain Reaction) in 37 children affected by KD and another 37 as control group, respectively.Result:1. The 10 clinical records in CAL group have no significant difference compared to lesion free group(P﹥0.05) . The Kobayashi score in CAL group is 1.75±1.65 compared to 1.66±1.55 in lesion free group, and there isn't significant difference, too(P﹥0.05).2. The frequencies of ACE genotypes (II, ID ,DD) in CAL group have no significant difference compared to both lesion free group and control group(P﹥0.05). Comparing allelic(I, D) frequencies, I allele was more prevalent in CAL group than in lesion free group(75%vs44.8%, P﹤0.05).3. The 10 clinical records have no significant difference in the tree genotypes of the ACE (P﹥0.05) .Conclusion:1. In Kawasaki group, both the 10 clinical records and the Kobayashi score were not statistically different between those with coronary artery lesion and those without2. ACE gene I/D polymorphism is thought to be associated with the development of coronary artery lesion in KD.