| Objective: To evaluate the effects of stereotactic radiotherapeutic models in the treatment of patients with brain metastasis from lung cancer,and to access the prognostic factors that correlated with survival. Methods: From August 2003 to December 2007,82 consecutive patients who presented with brain metastasis from lung cancer in our hospital received radiotherapy, include which 28 cases were stereotactic radiotherapy (SRT) alone,54 cases were stereotactic radiotherapy combined with whole brain radiotherapy(WBRT).In SRT group,the prescription dose ranged from 4Gy to 6Gy per fraction,with total dose 12Gy-30Gy.The dose of WBRT was 28Gy-32Gy in 14 to 16 fractions,1.8Gy-2Gy per fraction. Results: The local control rates in whole group was 63.5%; the median survival and the median of progression free survival(PFS) in whole group was 10 months and 8 months respectively. The local control rates in two groups were 54.5% and 67.2% respectively(χ2=3.765,P=0.037), which was increased in group SRT+WBRT;the median survival were 11, 10 months(χ2=0.00,P=0.985); the median of progression free survival(PFS) were 8 months in both groups(χ2=0.11,P=0.740); one-year survival in both groups were 42.9%,42.6% respectively(χ2=0.001,P=0.583).There were statistical differences in the death cause composing rate between the two groups(χ2=8.334,P=0.017), the extracrania factors played a main part in SRT group;while it was brain ones in SRT+WBRT group.Multivariate analysis showed pathologic type to be independent factor for overall survival. Conclusions: Stereotactic radiotherapy(SRT) was an effective method in the treatment of brain metastasis from lung cancer. Combining whole brain radiotherapy(WBRT) can increase the local control rate, but whether combining whole brain radiotherapy(WBRT) or not does not appear to compromise survival in our cases.Pathologic type was independent predictor for overall survival in brain metastasis.
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