The Study Of Influential Factors To Lymph Node Metastasis In Thoracic Segment Esophageal Sequamous-Cell Carcinomas

OBJECTIVE: To study the characteristics of lymph node metastasis in thoracic segment esophageal carcinomas and their relevance to clinical-pathological factors. METHOD: We retrospectively studied surgically treated 215 Thoracic Segment Esophageal Sequamous Cell Carcinoma (TSESCC) patients from Jan. 2006 to Jul. 2007 in the Department of Thoracic Surgery, Oncology Hospital of Xinjiang Medical University. Surgical, as well as pathological data are gathered and retrospectively studied using the SPSS for Windows 13.0 statistics software. The characteristics of lymph node metastasis and their relevance factors are determined. RESULT: The overall rate of LNM is 54.49%; the rates of LNM in upper segment carcinoma to cervical, mediastinal and abdominal cavity are 25%?20%?15% respectively. the rates of LNM in middle segment carcinoma to three fields are 10%?34.2%?27%,the rates in inferior segment are7.4%?52.94%?50%. There is clear relationship between the location of the cancer and the location of affected lymph nodes. Through bi-modal Logistic retrospective analysis, we decided that the depth of infiltration, degree of differentiation, location are the factors that affect LNM, Whether there are sex, ethnicity, history, body weight(losing), length of the tumor and macroscopic pathological type, lymph vessel infiltration has no significant affect on the LNM. We also discussed relationships among LNM, depth of infiltration and differentiation of cancer using Logistics Retrospective Analysis, making the relationship among the independent influence factors and LNM even clearer. CONCLUSION This study indicated that:1)Factors that influence the LNM are tumor location, tumor infiltration depth and degree of differentiation. 2)Factors like sex, race, body weight variations, length of the tumor, macroscopic pathology and infiltration to lymphatic vessels are have no obvious relation to LNM. 3)Thoracic Segment Esophageal Squamous Cell Carcinoma (TSESCC) affects lymph nodes in cervical, thoracic and abdominal cavities, but the most common site of LNM is the mediastinum, followed by the abdomen and the neck.