Expression Of SCP-1, GAGE-1 And CAGE In Glioma And Their Clinic Significance

OBJECTIVE: To investigate the expression frequency of Cancer-Testis Antigen (CTA) genes, SCP-1, GAGE-1 and CAGE in human glioma, and explore the potential of these three CTA genes for immunotherapy of glioma.METHOD: Fourty-nine specimens of human glioma and forteen specimens of relatively normal tissues from human brain were analyzed for the expression frequency of SCP-1, GAGE-1 and CAGE with Reverse Transcriptase Chain Reaction (RT-PCR). Correlation between the expression frequency of these three CTA genes and clinical datum including patients' age, sex and tumor grade was evaluated.RESULTS: There is no expression of in SCP-1, GAGE-1 and CAGE in relatively normal brain tissues. In glioma the expession of SCP-1 and GAGE-1 was as same as 8.16%, and tended to limit in the higher grade tumors. The expession of CAGE was 65.31%, which widely expressed in varity of glioma. There was no association between clinical data and expression frequency of these three CTAs, except for the patients' sex and expression frequency of CAGE.CONCLUSION: SCP-1 and GAGE-1 have higher expression frequency in higher grade glioma. CAGE can widely expressed in variety of glioma with highly expressive frequency. These three CTAs can be as the target antigens with the potential in immunotherapy of glioma.