| Objective①TO investigate the expression of p53,p21,p16,c-myc, cyclinD1 protein between familial hepatocellular carcinoma and non-familial hepatocellular carcinoma。②TO explore sensitive protein of familial hepatocellular carcinomaMethods Detecting the expression of p53,p21,p16,c-myc,cyclinD1 protein in 43 HCC patients including 9 familial aggregation HCC and 34 non-familial HCC using immunohistochemistry.Results①The positive expression rate of p53,p21,p16,c-myc and cyclinD1 protein in the hepatocellular carcinoma tissue was 53.49/%(23/43), 25.58/%(11/43),39.53/%(17/43),51.16/%(22/43),44.19/%(19/43)。The positive expression rate of p53,p21,p16,c-myc and cyclinD1 protein in surrounding carcinoma tissue was 6.98/%(3/43),60.47/%(26/43),62.79/% (27/43),30.23/%(13/43),23.26/%(10/43)。There was significant difference of the five protein between carcinoma tissue and surrounding carcinoma tissue (p＜0.05)。②The expression rate of p53,p21,p16,c-myc,cyclinD1 protein in carcinoma tissue was 55.56%(5/9),22.22%(2/9),55.56%(5/9),44.44%(4/9), 44.44%(4/9)in FH group。The expression rate of p53,p21,p16,c-myc, cyclinD1 protein in carcinoma tissue was 52.94%(18/34),26.47%(9/34), 35.29%(12/34),52.94%(18/34),15/34(44.12%)in NFH group。They were all no significant difference between FH and NFH(P＞0.05)。③The expression rate of p53,p21,p16,c-myc,cyclinD1 in surrounding carcinoma tissue was 11.11%(1/9),66.67%(6/9),44.44%(4/9),66.67%(6/9), 11.11%(1/9)in FH group。The expression rate of p53,p21,p16,c-myc, cyclinD1 in surrounding carcinoma tissue was 5.88%(2/34),58.82%(20/34), 67.65%(23/34),20.59%(7/34),26.47%(9/34)in NFH group~ There was no significant difference in p53,p21,p16,cyclinD1 expression between FH group and NFH group(P＞0.05)。But,there was significant difference in c-myc expression between the two group(P＜0.05).Conclusion①p53,p21,p16 and cyclinDt might to be not related to the familial aggregation HCC。②c-myc might to be related to the familial aggregation HCC。...
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