Studies On The Associated Factors Of Occurrence Of Familial Aggregative Hepatocellular Carcinoma AND Relationship Between GSTM1 Genotypes And Genetic Susceptibility To Hepatocellular Carcinoma

Objective: To study the relationship between the null genotypes of GSTM1 and the genetic susceptibility to HCC and compare the frequency of the null genetype of GSTM1 between familial aggregative hepatocellular carcinoma and sporadic HCC. Methods: The genotypes of GSTM1 of familial aggregative HCC and sporadic HCC and controls were detected with Multiple PCR technique. Rusults :The frequency of GSTM1 null genotype in sporadic HCC was 59.64% and 75.00% in familial aggregative HCC and 47.75% in controls. The difference was statistically significant Conclusion : Inheritance and environment contribute to the familial aggregation. The risk of HCC is associated with GSTM1 null genotypes, especially in people with family histories of HCC. Persons with GSTM1 null genotype have an increased susceptibility to HCC.