Relationship Between Gene Polymorphism Concerned 5-HT Transporter And Post-stroke Depression

Objective:To investigate the assosiation between serotonin transporter(SERT or 5-HTT)gene-linked polymorphism promoter region(5-HTTLPR),varied number tandem repeats(VNTRs)polymorphism within intron 2 and post-stroke depression(PSD),and to elucidate the effect of 5-hydroxytryptamine transporter (5-HTT)in the procedure of post-stroke depression(PSD).Methods:Research objects were divided into four groups:36 patients in PSD group;34 patients in stroke group;35 patients in depression group;29 patients in health control group Use polymerase chain reaction(PCR)and restriction fraction length polymorphism(RFLP)techicals,5-HTTLPR and VNTRs polymorphism of serotonin transporter gene were determined in all objects.All objects were diagnosed CCMD-3.Consequently,to analyze the correlation between these polymorphism and clinical feature according to Hamilton rating scale for depression(HRSD).Results:1.5-HTTLPR polymorphism of SERT gene:The frenquency of S/S genetype and S allele in PSD and depression group were significantly higher than that in stroke and health control group;the frenquency of L/L genetype and L allele in stroke and health control group were significantly higher than that in PSD and depression group;Extra long allele(XL)was found in patients with PSD and depression.2.VNTRs polymorphism within intron 2 of SERT gene:The frenquency of Stin_2.10/Stin_2.10genetype and Stin_2.10allele in PSD and depression group were significantly higher than that in stroke and health control group;the frenquency of Stin_2.12/Stin_2.12genetype and Stin_2.12allele in stroke and health control group were significantly higher than that in PSD and depression group.Conclusion:1.The presence of 5-HTTLPR L/L genetype and L allele probably carry an decreased risk of an development of PSD;The presence of 5-HTTLPR S/S genetype and S allele probably carry an increased risk of an development of PSD. 2.The presence of VNTRs within intron 2 of SERT Stin_2.12/Stin_2.12genetype and Stin_2.12allele probably carry an decreased risk of an development of PSD;The presence of VNTRs within intron 2 of SEPT Stin_2.10/Stin_2.10genetype and Stin_2.10 allele probably carry an decreased risk of an development of PSD.