Methotrexate Hydroxychloroquine And Total Glucosides Of Paeony Capsulesin In The Treatment Of Rheumatoid Arthritis Clinical Observation

Objective:To observe the methotrexate,hydroxychloroquine total Glucosides of Paeony Capsulesin(TGP)in the treatment of active rheumatoid arthritis(RA)the clinical efficacy and safety.Methods:Sixty cases of active rheumatoid arthritis patients were randomly divided into treatment and control groups.Treatment group of thirty patients to oral methotrexate methotrexate 7.5 mg,one week,hydroxychloroquine 0.2 g oral,two times a day,TGP(Pa Fulin)600 mg orally,three times a day.The control group of 30 patients to oral methotrexate 7.5 mg,1 week,hydroxychloroquine 0.2 g oral,twice a day,Observation of patients before treatment,three months after the treatment of Chen Jiang,several joint tenderness,joint swelling,the patients on the overall assessment of disease activity,the doctor on the overall assessment of disease activity, Observe the ESR,Rheumatoid factor quantitative,C-reactive protein and other laboratory indicators and the incidence of adverse reactions,including gastrointestinal reaction,neutropenia,abnormal liver function,eye diseases,and so on.We use the United States Institute of Rheumatology issued by the ACR20 criteria to evaluate the efficacy,We used SPSS 11.5 statistical software for newly diagnosed patients with the information and treatment three months after the results of statistical analysis.Results:①Two groups of patients have improved significantly with Chenjiang time, several joint tenderness,joint swelling the number of patients on the overall assessment of disease activity,the doctor on the overall assessment of disease activity three months after than before treatment,The treatment group of Chenjiang time, several joint tenderness,joint swelling the number of patients on the overall assessment of disease activity,the doctor on the overall assessment of disease activity than the control group②Two groups of patients with ESR,rheumatoid factor(RF) quantitative,C-reactive protein and other targets in the laboratory for three months after 3 months treatment has dropped significantly.Treatment group was significantly better than the control group.③Drugs were caused by adverse reactions to see more gastrointestinal reaction,mainly for anorexia,stomach discomfort,abdominal pain, diarrhoea,treatment group,four cases,while the control group five cases.2 groups showed no significant difference(P＞0.05),oral ulcer treatment group in two cases, while the control group is the four cases,two groups showed no significant difference (P＞0.05).None of the treatment group there neutropenia,liver and kidney damage and other side effects,while the control group in five cases,two groups was significant difference((P＜0.05).Two groups,the rate of adverse reactions to the treatment group 20 percent,significantly lower than the control group,46.7%.Conclusion:①Methotrexate+hydroxychloroquine+TGP treatment group and methotrexate+hydroxychloroquine control group,two groups can significantly improve the activities of rheumatoid arthritis symptoms,signs and laboratory Indicators.②Methotrexate hydroxychloroquine TGP treatment group to improve the treatment of patients with clinical symptoms,signs and laboratory indicators,is superior to methotrexate hydroxychloroquine group,and significantly reduce adverse reactions.③TGP has anti-inflammatory pain and inhibit their immune response and protection of the functions of the liver cells,and methotrexate hydroxychloroquine use can enhance the efficacy compliance with the increase and reduce the occurrence of side effects.