A Study Of RBC Polyunsaturated Fatty Acids And Children With Attention Deficit/Hyperactivity Disorder In China

Objective: To Discuss difference of Polyunsaturated fatty acid (PUFAs) in children with attention deficit/hyperactivity disorder (ADHD) in China and the correlation degree of PUFAs and clinical symptoms.Methods: 29 children with ADHD were classified according to the Fourth Edition of Diagnostic and Statistic Manual of Mental Disorder (DSM-Ⅳ) criteria, with age range of 6-12 years were involved in the study. 22 health children were matched by age as contro1.The two groups were examined using Conner's Parent Rating Scale(PRS), Wechsler memory scale(digits down-reciting and reversal reciting), Mini-Mental State Examination (MMSE) and Tail making test (TMT, A&B) to evaluate behavior problem, intelligence, the capacity of auditory short-term memory and working memory, complicated mission management. At the same time, in knowing the facts agreeing to fetch vein blood for 3 ml in two sets of children down respectively, and Determine the thickness of fatty acids in the red cytomembrane.Results:①In PRS, the scores of morality, learning, impulsion hyperactivity, and hyperactivity index were higher in ADHD group than health control (HC) (P<0.05).②In TMT, the ADHD children spent more time on part B than HC (P<0.05). The scores of digits reciting (train reciting, reversal reciting and the total scores) was lower in ADHD than HC (P<0.05).③The fatty acid 18:0 was more in ADHD than HC, and EPA, 22:5(n-3), DHA, n-6%, n-3% were fewer in ADHD than HC(P<0.05).④The score of learning in PRC was positively correlated with n-6/n-3, The score of impulsion-hyperactivity was negatively correlated with 22:5(n-3) and n3(P<0.05), and positively correlated with n-6/n-3 (P<0.01). the scores of hyperactivity index was negatively correlated with 22:5(n-3).⑤The time of TMT (B) was negatively correlated with 22:5(n-3) (P<0.05). The scores of digits reciting (train reciting) was positively correlated with 22:5(n-3), DHA and n-3%(P<0.05), and negatively correlated with n-6/n-3(P<0.01). The scores of digits reciting (the total scores) was positively correlated with 22:5(n-3), DHA, n-3%,and was negatively correlated with n-6/n-3.⑥The score of learning in PRC was positively correlated with the time of TMT (B) (P<0.05), The score of anxiety in PRC was negatively correlated with the scores of digits reciting ( reversal reciting and the total scores) (P<0.01).Conclusions:⑴The thickness of Some kinds of Polyunsaturated fatty acids (PUFAs) were lower ADHD children in China. The thickness of PUFAs were correlated with the behavior of ADHD children.⑵The thickness of PUFAs were correlated with the executive function of ADHD children such as working memory and complicated mission management.