Clinical-pathological Features With Serum And Urine Macrophage Migration Inhibitory Factor And Matrix Metalloproteinase-9 In Immune Kidney Disease

Immunological inflammatory damage is important reason for disease process in various primarily and secondary Immune Kidney Disease. macrophage migration inhibition factor as a pro-inflammatory cytokine,which high expression in Kidney lead to aggregate of megalophage and activate a series of inflammatory cytokine and excrete such as interleukin-1,Tumor Necrosis Factor-α,platelet activating factor.Matrix Metalloproteinase-9 as one important of matrix metalloproteinases,which is close correlation with sediment of extracellular matrix and accrementition of intercapillary cells in glomerulus of kidney.MIF and MMP-9 play an very important role in the process of glomerular sclerosis and nephric tubule damage and interstitial fibrosis,so Clinical-pathological features with MIF and MMP-9 in Immune Kidney Disease is a hot research recently.To determine the relationship MIF and MMP-9 levels with the disease progress,we measure MIF and MMP-9 levels in serum and urine of IgA-N and LN.and we Analyze the MIF and MMP-9 levels with Clinicalpathological features in IgAN and LN.Significantly increased serum and urine levels of MIF and MMP-9 were found in the IgAN and the LN patients as compared with the healthy controls (all P＜0.01),obviously urine MIF levels in active LN patients(P＜0.01);urine levels of MIF were increased by degrees fromⅠtoⅤclass of IgAN(p＜0.05)。 serum MMP-9 levels also had a going up trend fromⅠtoⅣclass,MMP-9 levels inⅣclass is significant higher thanⅠ-Ⅲclasses(P＜0.05),There was notable correlation between MIF and MMP-9 in serum(r=0.484,P＜0.01), There were significant correlation between urine MIF concentration and TUP,crescent formation,mesangial Cellular proliferation(r=0.637, P＜0.01;r=0.482,P＜0.01;r=0.542 P＜0.05);serum and urine levels of MIF in patients with SLE active was notable higher than that in patients with stable disease(P＜0.01,P＜0.01),There were significant correlation between serum /urine MIF concentration and SLEDAI,TUP,C3,C4,Ds-DNA-antbody,Ig-G(r=0.598,P＜0.01,r=0.641,P＜0.01;r=0.524,P＜0.01,r=0.749 P＜0.01 r=-0.36,P＜0.05,r=-0.19,P＜0.05;r=-0.52,P＜0.01,r=-0.57,P＜0.05; r=0.59,P＜0.05,r=0.69,P＜0.01;r=0.37,P＜0.01,r=0.42 P＜0.01), There were significant different between before and after treatment in levels of serum/urine MIF with 22 SLE active patients(P＜0.01).We conclude that overexpression of MIF and MMP-9 in vivo in Immune Kidney Disease associated with Clinical-pathological damage proceeding.we also conclude overexpression of MIF and MMP-9 is one of the important molecular biology mechanisms in Immune Kidney.