The Changes And Clinical Significance Of Serum S100B Concentration In Hypoxic-ischemic Encephalopathy Of Neonate

Objective:To investigate the change of serum S100B and brain CT value in patients with HIE,as well as the variations of them.It can be used to provide the evidence in early diagnosis,evaluate the degree of brain damage and guild treatment of HIE.Methods:We detected the level of serum S100B by ELISA in 30 HIE patients and 10 control full-term infants,CT values of all the patients were obtained with huanxing Simens type of CT meanwhile,collected the clinical information completely.Results:①The serum level of S100B in control group was 0.44±0.23μg/L.The level of S100B in mild HIE group was 0.86±0.24μg/L whereas that of moderate-severe HIE group was 1.78±0.33μg/L in the acute period.There was significant difference among them(P＜0.01).②There was significant difference of S100B concentration between the mild HIE group and the control group during the acute period(P＜0.01).There was significant difference of S100B concentration between mild HIE group and moderate-severe HIE group during the acute period (P＜0.01).③The serum level of S100B in moderate-severe HIE group in acute period was 1.78±0.33μg/L,which dropped to 0.68±0.32μg/L in recovery period.There was significant difference between them(P＜0.01).The serum level of S100B of mild HIE group in acute period was0.86±0.24μg/L,which declined to 0.47±0.11μg/L in recovery period.There was significant difference between them(P＜0.01).④The brain CT values of the moderate and severe HIE group were lower than the mild group.With correlation analysis,negative corre- lations were founded between serum S100B and brain CT values.The correlation coefficient was -0.662.Conclusion:①The serum level of S100B in HIE patients are higher obviously than non-HIE groups,which shows that it participates in the path physiological process of neonate hypoxic-ischemic encephalopathy.②There are close relationships between the change of S100B and the patient's condition,course of disease.It is significant to supervise the trends of S100B for judging the state of disease and directing treatment in early stage of HIE.③There are negative correlation between S100B and CT scan value,they both are useful for judging the state of disease.