Preparation And Characterization Of Biological Membranes From Collagen

Collagen is the most abundant mammal protein, nearly about 20%³0% in the body. It is the basis component of the skin, cartilage, artery afferent wall and knot organization, there are various function in the animal body, such as support and protection, conjunction…etc. Besides, it also can be made into the material of different form, like memrane, sponge, cingulum, thin slice etc.. The membrane can be applied into parenchyma aggrandize, blood vessel and wound dressing, skin disfigurement recuperate. Except the biologically suitability, this material can help the reconstruct of damage tissue, and its physics characteristic is also similar with the substitutional tissue.Glutin is the outcome that the collagen disorganization, some of its contracture and property was similar with collagen. It's composed with 20 kinds of amino acidses, among them, 1/3 was glycin, 1/3 was proline and hydroproline. Mostly element wasα₁,α₂,βandγcomplement, who easily dissolved in water, having the good characteristic that dissolved gum and gel can conver to each other along with the tempreture going up or lower, drily, presents a transparent form and has certain machine strength, acquire a very extensive application in exposed to light industry, the medicine industry, the food industry and other industry.This thesis chooses KH-560 as to act with glutin. It is mainly used to improve organic and inorganic materials surface connect function and, can raise machine and mechanics function of ware. This thesis we still adopt Polyglycol, Chitosan and Polyvinyl alcohol to change the properties of menbrane which compounded by glutin and KH-560.Polyglycol is the polymer of glycol and ethane, is used to increase humidity and absorb moisture and to strengthen the membranes intensity and stability. The chitosan is the only alkaline amylose in the nature, can decline in the body, have good biocompatibility, low toxicity, high mechanical strength and good film-forming ability. There are many amido in the chitosan member, can fome Sehif alkali gelatin. PVA is the water solubility macromolecule polymer, which is innoxious and has a good biological adaption. These materials all can obviously improve the mechanics and dissolve property of glutine membranes. They can be made into cover materials and as the carrier of some less stability products. Along with the development of organization engineering, the polysaccharide and PVA will be used in many areas, such as cell incubate, framewoke and biological materials release, for its unantigentic,In this paper, transport ratio, tensile strength, rupture elongation ratio were determined. The results indicated that the polyglycol can increase mechanical properties of. the membranes. Chitosan can enhance mechanical properties greatly, but the membranes transport ratio is lowest. The amido, hydroxide, and–C-O-C- groups in chitosan can act with carboxyl in glutin. PVA can enhance the membranes taansport ratio, and the other mechanical properties, such as peak load, breakpoint load, elongate rate, distensibility all are most.