Plasma C-reactive Protein Level And The 1059G/C Polymorphism Of CRP In Patients With Cerebral Infarction

Objective To explore the relationship between the C-reactive protein levels, 1059G/C (rsl800947) gene polymorphism and cerebral infarction.Methods A case-control study on 105 patients with cerebral infarction and 121 healthy controls was carried out. The high-sensitive C reactive protein was determination by immune-turbidimetry, the genotype and allele frequencies of CRP 1059G/C gene polymorphism were assayed by polymerase chain reaction-restricted fragments length polymorphism (PCR-RFLP). All the patients were measured with National Institutes of Health Stroke Scale(NIHSS).Results There were statistically significant for CRP 1059G/C genotype frequencies between the patients with cerebral infarction and the healthy controls(P<0.05). The allele frequencies of CRP 1059G/C was G 96.67%,C 3.33% in patients with cerebral infarction. The C allele of cerebral infarction patient was less than the control group. There were statistically significant that High-sensitivity CRP levels with stroke severitest for National Institutes of Health Stroke Scale was higher than the others (P<0.05).However, there were no statistical significant difference that neither CRP genotypes nor alleles showed an association with patient's condition(P>0.05). The risk factors for cerebral infarction, including history of hypertension,diabetes, smoking, HDL-C,h-s CRP level, CRP 1059 G/C+C/C genotype.Conclusion 1. There were statistically significant for CRP 1059G/C genotype frequencies between the patients with cerebral infarction and the healthy controls. The C allele in the patient with cerebral infarction was significantly less than the control group. 2.High-sensitivity CRP levels was associated with stroke severity. 3. For han of Chinese, the CRP 1059 G/C+C/C genotype was a risk factors for cerebral infarction.