The Expression Of UPAR And BRCA-1 In Tissue Of Epithelial Ovarian Tumour And Its Significance

Objective: It was to observe the expression and sense of UPAR,BRCA-1 in tissue of Epithelial Ovarian Tumour and its correlation.Methods: BRCA 1 and uPAR protein expressions were detected in 69 epithelial ovarian tumours. Kaplan-Meier method was used to analyze the relationship between their expressions. Spearman's method was used to analyze its correlations.Results: 1.BRCA1 positive expression rates were 33.3% (14/42)in ovarian cancers, 60 % (9/15)in borderline epithelial ovarian tumour, and 83.3 %(10/12)in benign epithelial ovarian tumour respectivdy. The positive rate of BRCA1 protein in ovarian cancer was lower than that in benign and borderline epithelial ovarian tumours。(P<0.05)。2.The positive rate of uPAR expression in ovarian cancer is 83.3% (35/42),53.3%(8/15) in borderline epithelial ovarian tumour,and 25% (3/12) in benign epithelial ovarian tumour respectivdy.3. The expression of BRCA1 was negative correlated wth uPAR in epithelial ovarian cancer (r=-0.350, P<0.05) The positive rate of uPAR protein in ovarian cancer was higher than that in benign and borderline epithelial ovarian tumours。(P<0.005)。Conclusion: 1. The high expression level and intensity of uPAR at the early stage and good play differential grade ovarian cancer tissue showed that uPAR may, at least,played a important role at the early stage. 2. The low expression of BRCA-1 in ovarian cancer tissue showed that BRCA-1 might play an important roles in the infiltration,metastasis of epithelial ovarian cancer.3. The expression level and intensity of uPAR was negative correlated to BRCA-1 in the epithelial ovarian cancer tissue,showde that they may played important roles in the infiltration,metastasis of epithelial ovarian cancer in different ways.