Study On The Expression And Correlation Of UPA,uPAR And PAI-1 In Endometriosis

ObjectiveEndometriosis, one of the most frequent gynaecological diseases that affects women of reproductive age, results in dyspareunia, chronic pelvic pain, dysmenorrhea and infertility. Recently, the incidence rate of endometriosis has been increasing and affected women suffer a lot from it. Endometriosis is a benign disorder, with malignant activity such as migration, implantation and growth et al. Little is known about the pathogenesis of endometriosis. Therefore, it is difficult to be cured completely. However, it is thought that retrograde menst(?)ation may transport endometrial tissue to ectopic locations. By degrading extrallular matrix, the endometriotic tissue may be able to implant and invade peritoneum and the surrounding structures. The urokinose plasminogen activator system (uPA system) may play an important role in this process.The uPA system, including urokinose plasminogen activator (uPA), urokinose plasminogen activator receptor (uPAR), plasminogen activator inhibitor type-1(PAI-1), is involved in tissue degradation and remodeling under both normal and pathological conditions. uPA ,a proteolytic enzyme, activates plasminogen to the highly protent plasmin which may degrade extracellular matrix(ECM) and basement membrane involved in cell migration, tissue remodeling, the cleavage of nomal and pathological tissues and angiogenesis. uPAR is a new proteolytic factor and its structure contributes to movement of receptors on cell membrane. The activation of plasminogen , leading to the formation of plasmin is catalyzed by uPA when bound to uPAR. uPA binds to uPAR with high affinity, and receptor binding of uPA initiates pericelluler proteolysis , cell migration, tissue remodeling and angiogenesis that prepare for...