The Observation Of Lung Protection Of Patients Undergoing Pulmonary Hypertension Atomized Inhale L-arginine Aftercardiopulmonary Bypass Surgery

Objective To observe the clinical effects of patients undergoing congenital heart disease combined with pulmonary hypertension atomized inhale L-arginine after CPB surgery.Methods patients undergoing congenital heart disease combined with pulmonary hypertension were divided into two groups randomly. Patients in Group A inhaled L-arginine(200mg/kg) when connected for mechanical ventilation after CPB surgery. Patients in Group B inhaled equivalent dose of sodium chloride as the control. Oxygen index(OI), alveolar-arterial PO2 difference(P_A-aO₂), intrapulmonary shunt fraction (Q_S/Q_t) were figured out according blood gas analysis on the T₀(preoperation),T₁(2h after inhalation) and T₂(12h after inhalation) respectively .the concentration of nitric oxide (NO) and malondialdehyde (MDA) in serum were detected on T₀,T₁,T₂ respectively.Results the mean pulmonary artery pressure(MPAP) were drawdowned significantly (P<0.01) in group A. the concentration of NO in serum upgrade in grupe A while MDA were descent(P<0.05) ,and the control shows the opposite. P_A-aO₂ and Q_S/Q_t in grupe A were lower than the control (P<0.05). 01 in grupe A show the better promotion significantly than the control.Conclusions atomized inhalation of L-arginine have positive effects in pulmonary hypertension therapy , and have beneficial aspect for improving the lung function.