| Objective: Ankle-Brachial Index(ABI) measurement is the most exactly invasive examination index in screening and diagnosing peripheral artery disease(PAD). In recent years, many large scale clinical studys find that there is significant association between ABI and cardiovascular and cerebro- vascular diseases. There were lots of methods for ABI measurements, Doppler and Oscillometric measures were commonly used recently. Whereas, few studys were performed on comparing the two measures in a general population. This study compwered the ABI results measured simultaneously by consecutive Doppler measurement(Mode: DopplexⅡ) and automated oscillometric technique(Mode:VP-1000;BP-203RPEⅡ) to choose an accurate, convenient, pragmatic and economic measure commonly used in community performance.Method: We enrolled 1 006 subjects from inhabitants of three Beijing communities during July and September in 2007, excluding inhabitants with amputation surgical trauma who were unsuitable or unable to measure ABI and patients with serious diabetes, ketoacidosis, secondary hypertension, 1-type diabetes. We collected general information of all the subjects: including general state of health such as sex, age, body height and body weight, hypertension, hyperlipoidemia,history of diabetes mellitus, stroke, coronary heart disease and smoke. Mensurated blood glucose, total cholesterol, low density lipoprotein, high density lipoprotein, triglyeride with venous blood drawed on an empty stomach. In addition, we measured ABI results of the same subject using Doppler and Oscillometric measurement. After collecting all the information, we analysed the consistency of the ABI values measuredby the two measurements using spss 10.5.Results: (1) 1 006 subjects included 339 males(33.7%) and 667 females(66.3%) with age range from 23 to 83(54.8±11.3y) years old, body weight range from 13.3 to 39.9(25.7±3.8), brachial systolic blood pressure range from 90 to 224 mmHg(136.7±19.5mmHg), ankle systolic blood pressure range from 82 to 238 mmHg(152.7±24.7 mmHg), total cholesterol range from 1.18 to 8.23 mmol/L(5.01±0.96 mmol/L),low density lipoprotein range from 0.81 to 6.72 mmol/L(2.53±0.70 mmol/L),high density lipoprotein range from 0.59 to 3.36 mmol/L(1.31±0.32 mmol/L),triglyeride from 0.26 to 16.78 mmol/L(1.79±1.65 mmol/L). Of all the subjects, 330(32.8%) were patients with hypertension, including diagnosed hypersetion patients before and subjects with blood pressure higher than normal value, 250(75.8%) taking hypotensive drug regularly. 201(20.0%) were patients with diabetes, including diagnosed diabetes before and subjects with empty stomach blood glucose higher than normal value. 75(7.5%) were patients with coronary heart disease, 74 were patients with cerebral arterial thrombosis. 347 were smokers, 174 of which had quit cigarette. 121 were regular alcohol intaker. (2) Ankle systolic blood pressure measured by Doppler method was 135.2±22.5mmHg,Brachial systolic blood pressure measured by Doppler method was 139.7±20.3mmHg, Ankle systolic blood pressure measured by Oscillometric method was 154.8±29.81mmHg,Brachial systolic blood pressure measured by Oscillometric method was 142.7±18.2mmHg. Brachial systolic blood pressure measured by the two method has no significant difference(P=0.57), Ankle systolic blood pressure measured by the two method has significant differrence(P<0.05). (3) In the 1 006 subjects, there were 8 persons(0.8%)whose ABI readings were not better than 0.9 measured by Doppler method, there were 9 persons(0.9%)whose ABI readings were not better than 0.9 measured by Oscillometric method, there were 7 persons(0.7%) whose ABI readings were not better than 0.9 measured by the two methods simultaneously(including 2 patients with intermittent claudication), there was no statistic difference in the resuts of ABI≤0.9 measured by the two methods(P=0.20). (4) The cumulative distribution of the ABI measured by the two methods demonstrated that the differences among them were not homogeneously distributed across the range of ABI value. The Doppler and oscillometric ABI readings were similar below values of 0.9, at values between 0.9 and 1.16 ,the readings were nearly the same line, whereas at values exceeding 1.16, the readings were not parallel. (5) The mean of oscillometric minus Doppler ABI were 0.009(95%CI -0.24～0.2), extremely close to 0, besides, 48(4.8%) were not included in the 95% confidence interval, within the error permission, indicating a better consistency between the two measures. (6) Multivariant linear regression analysis indicates that there was association between male and ABI measured by either oscillometric or Doppler measure. Besides, ABI measured by Doppler measure was strongly associated with blood pressure(P=0.04) and smoking (P=0.001), ABI measured by oscillometric measure was associated with age(P=0.004).Conclusion: This study demonstrates that the ABI results measured by Doppler or oscillometic method have a better consistency in diagnosing and eliminating persons with peripheral artery diseases in a general population, they could be substituted mutually. Consecutive Doppler measurement has merit of accuracy, convenience, practice which is suitable for community performance.
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