Expression And Clinical Significance Of EGFR, β-tubulin And ERCC-1 In Non-small Cell Lung Cancer Tissues

Objective:To investigate and discuss the expression and their clinical significance of epidermal growth factor receptor(EGFR),β-tubulin,excision repair cross complement -1(ERCC-1)in non-small cell lung cancer(NSCLC)tissues.Methods:Expression of EGFR,β-tubulin and ERCC-1 in 92 NSCLC tissues was measured by Immunohistochemical Envision method.Results:1,The positive rates of EGFR,β-tubulin and ERCC-1 in NSCLC were 76.1%,73.9%and 40.2%,respectively.The positive rates of EGFR and ERCC-1 were higher in NSCLC than those in normal lung tissues(P＜0.05).the positive rate ofβ-tubulin in NSCLC is lower than that in normal lung tissues,no significant relationship was observed(P＞0.05).2,NO significant relationship were observed in expressions of EGFR,β-tubulin and ERCC-1 of histological classification between squamous cancer and adencarcinoma.The positive rate of EGFR in early stage was lower than in late stage, the positive rates of EGFR in Lymph node metastasis positive group is higher than that in negative group,the positive rate ofβ-tubulin in mediate-high differentiation is higher than in low differentiation,(P＜0.05).3,A total of 35 patients with NSCLC were treated with chemotherapy of Cisplatin contained regiment.The response rate in negative group(low-expression)/positive group(over-expression)of EGFR,β-tubulin and ERCC-1 were 38.5%/22.7%, 33.3%/26.9%,34.8%/16.7%(1.7,1.2 and 2.1 times,respectively,(P＞0.05).4,The long-term curative effect(1-year survival rates,2-year survival rates,median survival duration)of low -expression group of EGFR and over expression group were 30.8%,15.4%,12.5month and 36.3%,18.2%,11.2month,respectively.The long-term curative effect of negative group ofβ-tubulin and positive group were 44.4%,11.1%, 10.3month and 30.9%,19.2%,11.8month,respectively.The long-term curative effect of negative group of ERCC-1 and positive group were 39.1%,21.7%,10.4month and 25%,8.3%,9.5month,respectively.There were no significances of long-term curative effect of the three proteins between the two corresponding groups(P＞0.05). Conclusion:1,Over-expression of EGFR concerned with the development and progression of non-small cell lung cancer.Low-expression ofβ-tubulin maybe concern with growth and invasion of lung cancer.2,There is overexpression of multiple drug resistance-related proteins in NSCLC. Combining detection is helpful to the choice of the drug of chemotherapy and prediction of prognosis.