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Studies On The Pharmacy Of The Drug Couple Of Flos Puerariae And Semen Hoveniae

Posted on:2009-09-04Degree:MasterType:Thesis
Country:ChinaCandidate:X H YaoFull Text:PDF
GTID:2144360245950088Subject:Pharmacy
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This paper Flos Puerariae and Semen Hoveniae study in the literature on the basis of their research was herbal medicine, herbal medicine quality standards, extraction and purification of total flavonoids, and chemical fingerprinting Components of such content, aimed at establishing Flos Puerariae Semen Hoveniae and the quality standards of medicine and the pharmaceutical drugs on the preliminary study, to effectively control the quality of ingredients, a better understanding of their main effect of the material foundation for the full development its medicinal resources and provide a theoretical basis.Flos Puerariae for legumes kudzu Puerarialobata (Willd.) Ohwi flower, spent only on the《Ming yi bie lu》By the《Chinese medicine Buban standards》contains. Its function as dealcoholic Xingpai, liquor treat fever Fanhe and not to diet, vomit inverse acid vomit, blood, intestinal wind blood, traditional medicine is the most representative of the dealcoholic drugs. This herbs can Qingwei in the heat, while the appetizer-in-gas, and it could be evil administration in a positive light hot, stomach-or-not the disease. Semen Hoveniae of plants for Hovenia dulcis Thunb with succulent ripe fruit drying the fruit or seeds, first described in《Xin xiu ben cao》by the《People's Republic of China Ministry of Health Drugs standards·Chinese herbal medicines》contains. Semen Hoveniae as a traditional medicine and is widely used in civil. The materials have Qingre diuretic, and the effectiveness of anti drug, the head of liquor, Fanre, thirst, vomiting, then the negative of these liquor treatment of the most common is their effectiveness. This paper Flos Puerariae and Semen Hoveniae of medicine and quality standards are imperfect, no determination of these deficiencies, further improve their quality standards, And Flos Puerariae Semen Hoveniae of drugs on a preliminary study pharmacy. The collection of 10 different areas of medicine, a TLC; identified impurities in medicine, water, ash and acid insoluble ash limit of the alcohol-content of leaching; established by UV-visible spectrophotometry Determination of Flavonoids in medicine methods and Determination of Flavonoids in medicine content to enhance Flos Puerariae Semen Hoveniae of medicine and the quality control.Flos Puerariae and Semen Hoveniae of total flavonoids in the extraction and purification process were studied and inspected a different ethanol concentration, solvent volume times, and the extraction time from the total number of flavonoids extract yield and purity of the impact of the establishment of a four orthogonal factors and three levels of tests, and ultimately establish the best extraction process. And using macroporous resin to the total flavonoid extracts were purified with a selection of different types of resin, inspected the resin static and dynamic adsorption properties, and the kind of concentration and flow rate, concentration and solvent elution volume , and other related factors were optimized, and established the best purification process.The origin of the 10 Flos Puerariae Semen Hoveniae and the corresponding total flavonoids extract (intermediate), the HPLC fingerprint of research, through the optimization of the conditions established by their fingerprints and detection methods, the calibration respectively there are peaks, to control the quality of herbal medicine. Referring to "Technical Specifications of Fingerprint Study of Chinese Traditional Medicine Injection (Interim Regulation)" decreed by SFDA and similarity evaluation system for chromatographic fingerprint of TCM(2004 A)set by China pharmacopoeia committee, the results showed the similarity of Flos Puerariae and Semen Hoveniae and their total flavonoids extracts (intermediate)were both from0. 9 to 1.0.In chemical constituent' s studies, Flos Puerariae from two isolated isoflavones components, and its corresponding structural analysis or confirmed, can be used as medicine and the indicators of quality control components. The more systematic study of chemical constituents of Flos Puerariae and Semen Hoveniae is necessary in future.
Keywords/Search Tags:Gehua, Flos Puerariae, Zhijuzi, Semen Hoveniae, drug couple, quality standard, total flavonoids, fingerprint, chemical constituents
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