The Effects Of Xingchi Decoction With Acupuncture On MMSE, Hcy And EEG Of The Patients Of Alzheimer's Disease

Objective:Alzheimer' s disease is one of the degenerative disease of nervous system found firstly and nominated by Alois Alzheimer in 1907.With the aging of world population,the incidence rat-e of AD.shows rising constantly tendency,Now AD list 4th of cause of death(second only heart disease,tumor and apoplexy),become one of the most severe questions of geriatric medicine faced with.My tutor Prof.Liu Youzhang is good at the treatment of senile disease, thinking that AD patients have kidney and spleen asthenia to different degree. So aiming at the pathological element of spleen and kidney asthenia,weakness of Qi,blood,Yin and Yang,brain loss the nourishment,phlegm and blood stasis blocking the upper orifices of AD patients,Prof.Liu Youzhang created treatment method of tonifying spleen and renal,dissipating phlegm and removing blood stasis and empirical formula xingchi Decoction combined,with acupuncture Baihui,Sishencong,Shenting etc acupoint for early treatment, displayed better clinical effects.So in this research,we adopted xingchi Decoction combined with acupuncture to treat 20 slight of midrange AD patients of both the spleen and kidney asthenia,phlegm and blood stasis blocking clear orifices on the basis of routine western medicine,and randomized control with 20 simple traditional Chinese medicine group,20 simple western medicine group, so as to further approaching the effects and possible mechanism of xingchi Decoction combined with acupuncture in treating AD of both the spleen and kidney asthenia,phlegm and blood stasis blocking clear orifices.Methods:The research consists of two parts:literature review and clinical research.In literature review,we made systematic summary on recognition of etiology and pathogenesis of AD ofmodern medicine,blood biochemical marker related to AD,neuroimaging and electrophysiological change of AD,the discuss of traditional Chinese medicine on AD,traditional Chinese medicine and acupuncture therapy progress and the advantages of traditional Chinese medicine therapy etc.In clinical research,we made clinical observation of 60 slight of midrange AD patients of both the spleen and.kidney asthenia,phlegm and blood stasis blocking clear orifices,60 AD patients were randomly divided into 3 groups:20 simple traditional Chinese medicine group,20 simple western medicine group and 20 combination of traditional Chinese medicine and western medicine group.We adopted xingchi Decoctioncombined with acupuncture to treat AD in simple traditional Chinese medicine group;adopted aricep,duxil,pisacetam tablets for oral administration in simple western medicine group and western medicine combined with xingchi Decoction and acupuncture in combination of traditional Chinese medicine and western medicine group,3 groups' course of treatment were 4 weeks.Results:After 4 weeks treatment,traditional Chinese medicine therapeutic effects, improvement of measuring scale score of mini-mental state examination and detection index of AD patients(blood plasma homocysteine,EEG)were all better in combination of traditional Chinese medicine and western medicine group compared with simple traditional Chinese medicine group and simple western medicine group(P＜0.05).Conclusion:On the basis of routine western medicine,the effects of combination of traditional Chinese medicine and western medicine of xingchi Decoction combined with acupuncture were definite in treating slight of midrange AD patients of both the spleen and kidney asthenia,phlegm and blood stasis blocking clear orifices.There were no adverse effects in clinical research. and it can be used as conventional therapy plan for AD patients.