Study On Pharmaceutical Technology And Quality Evaluation Of Micronized Powder Of Panax Notoginseng (Burk.) F.H. Chen And Panax Quinquef Olium L.

Panax notoginseng(Burk.)F.H.Chen and Panax quinquef olium L.are valuable herbs.They are memebers of the plant family Araliaceae and recorded in the Chinese Pharmacopoeia,2005.Panaxnotoginseng(Burk.)F.H.Chen is used to dredge and stop bleeding,relieve pain and detum-escence.It's processed product can also enhance the health and immunity.Panax quinquef olium L.can promote the production of body fluid to quench thirst,eliminate inflammation.TCM can be grinded by ultra-fine pulverization to 0.1～75μm,the cell-wall of plant is broken completely and to become microparticles.Every microparticle contains chemical constituents with the same property,so it is in the state of high uniformity.The Micronized Powder is belong to a new medicinal slices of TCM for it's characteristics.Study on Micronized Powder of TCM and it's shaped product was carried out by Zhongzhi Chinese Medicine CO.,LTD.since 2004.The company developped series of products "New Medicinal Slices of TCM-Granule of Cell Breaking powder" and established a economic scale of production of this series of product.Good economic benefit was obtained.In the process of study and manufacture,suitable varieties of TCM to be ultrafine grinded were already selected,standardized technological procedures and enterprise standards were established.The further study of manufacture and research of Micronized Powder will be carried out.The quality of Micronized Powder of TCM is restricted by many factors.For the purpous of improving standardized technological procedures and internal controled quality standards,we carried out reseach on pharmaceutical technology and quality standard of Micronized Powder of Panax notoginseng(Burk.)F.H.Chen and Panax quinquef olium L..Section two Experimental StudyChapter one Screening program of resources about medical materials of Micronized Powder of Panax notoginseng(Burk.)F.H.Chen and Panax quinquef olium L..To fix the resources about medical materials of Micronized Powder of Panax notoginseng(Burk.)F.H.Chen and Panax quinquef olium L.by consulting the relative literatures and datas and government standard and agricultural standard for fixing it. Chapter two Study on pharmaceutical technology for Micronized Powder of Panax notoginseng(Burk.)F.H.Chen and Panax quinquef olium L..2.1 Object To establish of standardized technological procedures of Micronized Powder of Panax notoginseng(Burk.)F.H.Chen and Panax quinquef olium L..2.2 Method To optimizate a series of technology parameters of Micronized Powder and shaped product of Panax notoginseng(Burk.)F.H.Chen and Panax quinquef olium L..2.3 Result and Conclusion It's the core technique material of enterprise organizational capability,so we must keep secret.Chapter three Study on quality evaluation metheod of Micronized Powder of Panax notoginseng(Burk.)F.H.Chen.3.1 Object To analyze advantages and disadvantages of Micronized Powder of Panax notoginseng(Burk.)F.H.Chen and suggest solutions.3.2 Method The study was performed on Comparison of quality of Micronized and Fine Powder of Panax notoginseng(Burk.)F.H.Chen,a series of index such as sensory evaluation,extracts content,effective components,micro characteristics,angle of repose, particle size distribution,hygroscopic property are studied and analyzed.The study was performed on Comparison of quality of Micronized and Fine Powder of Panax notoginseng (Burk.)F.H.Chen about stability,a series of index such as extracts content,angle of repose, moisture content,effective components are compared and analyzed.3.3 Result The Micronized Powder of Panax notoginseng(Burk.)F.H.Chen is exquisite,color light.It's three effective components and extracts content are higher than that of fine Powder of Panax notoginseng(Burk.)F.H.Chen;But Micronized Powder of Panax notoginseng(Burk.)F.H.Chen is prone to conglomerate and in a state of high moisture absorption.It's shaped product is more stable in the change of extracts content,angle of repose,moisture content,effective components.Shaped product's qaulity is better than that of Micronized Powder.3.4 Conclusion The qaulity of the Micronized Powder of Panax notoginseng(Burk.) F.H.Chen is better than that of Fine Powder of Panax notoginseng(Burk.)F.H.Chen,but it is prone to conglomerate and in a state of high moisture absorption,forming technique can solve this problem.Chapter four Formulation of quality control standard of The Micronized Powder of Panax notoginseng(Burk.)F.H.Chen.3.1 Object To control the quality of The Micronized Powder of Panax notoginseng (Burk.)F.H.Chen.3.2 Method To formulate the quality standard,it's standard draft and it's description,the main contents include:the palce origin of medical material,identification,examination, extract content,particle size distribution,content determination,microbial limit and so on.3.3 Result and Conclusion This standard has a certain reference value for quality control and practicle manufacture.Chapter five Study on quality evaluation method of Panax quinquef olium L..3.1 Object The particle size distribution of The Micronized Powder of Panax quinquef olium L.and the differences of solubility beteewn the Micronized Powder and Fine Powder of Panax quinquef olium L.were studied.3.2 Method Laser size detector was used for detecting the particle size distribution,the differences of water-soluble extract content were compared between Micronized Powder and it's sharped product.3.3 Result The particle size distribution of Panax quinquef olium L.D₉₀＜10μm, water-soluble extracts content of the Micronized Powder and Fine Powder of Panax quinquef olium L.is higher than that of the sharped product.3.4 Conclusion Maybe there are some problems in pelletization influenced the solubility of the Micronized Powder.We should repeatedly determinate water-soluble content of Panax quinquef olium L.for explaining the cause and discussing solutions.