The Research Of The Plasma D-dimer And Fibrinogen Level In Patients Of Type 2 Diabetes Mellitus With Hypertension

ObjectiveTo evaluate the plasma D-dimer and fibrinogen level in the patients of type 2 diabetes mellitus with hypertension and investigate their correlation.Method85 subjects were divided into three groups according to clinical manifestation:①control group:20 subjects;②type 2 diabetes mellitus group:21 subjects;③type 2 diabetes mellitus combined with hypertension group:44 subjects.To further investate the relationship between the blood pressure and plasma level of D-dimer or fibrogen in the diabetetic hypertension patients,we also divide the group3 into three subgroup:ⅰ.stage 1 hypertension(SBP:140-159 mmHg or DBP:90-99mmHg)group:16 subjects;ⅱ.stage 2 hypertension(SBP:160-179mmHg or DBP:100-109mmHg) group:14 subjects;ⅲ.stage 3 hypertension(SBP≥180mmHg or DBP≥110mmHg)group:14 subjects;We measure the plasma D-dimer and fibrinogen level of each group,and compare between groups.The results were show as(?)±s,and we use ANOVA Test for comparing(SPSS 13.0).ResultsD-dimer:plasma concentrations was higher in single type 2 diabetes mellitus than those in normal control cases(P＜0.05):and in type 2 diabetes mellitus combined with hypertension cases had obvious difference(P＜0.01);and between single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension cases,the plasma concentrations of D-D was also higher than controls(P＜0.05).Fibrinogen: plasma concentrations was higher in single type 2 diabetes mellitus than those in normal control cases(P＜0.05);and in type 2 diabetes mellitus combined with hypertension cases had obvious difference(P＜0.01);and between single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension cases,the plasma concentrations of fibrinogen was also higher than controls(P＜0.05). subgroup:the plasma level of D-dimer and fibrinogen of stage 3 hypertension was significantly higher than stage 1 hypertension group.There were no obvious difference between other groups.ConclusionThe plasma levels of D-dimer and fibrinogen were related to type 2 diabetes mellitus with hypertension,had difference in different level of hypertension,they may play an important roles in forecast and diagnosis.for thrombosis diseases.