Clinical Significance Of D-dimer And C-reactive Protein In Prediction Of Prognosis Of Critically Ill Patients

Objective: This study measured the levels of C-reactive protein and D-dimer and documented SOFA and APACHEII score to explore the the relation to the severity of disease and prognosis.Methods: A total of 30 patients were selected in acute emergency unit in Da Lian Centle Hospital from September of 2008 years to April of 2008 years. 50 patients with SIRS and 15 Patients with no-SIRS as control group were included. According to prognosis, patients with SIRS were divided into good prognosis group and bad prognosis group. The level of C-reactive protein and D-dimer in serum was measured within 24 hours. All patients were scored by acute physiology and chronic health evaluationⅡ(APACHEⅡ) and sequential organ failure assessment (SOFA) . Their prognosis were evaluated when they leaved hospital.Result:(1) The level of CRP and D - dimer were higher in the patients with SIRS than in those without SIRS, there were statistically significant differences ( P < 0.05).(2) There was an obvious increase of CRP and D - dimer in the patients with bad prognosis as compared with those with good prognosis .(3) There was significant correlation between serum CRP and D - dimer and APACHEⅡor SOFA in all patients.Conclusions:(1) Serum levels of CRP and D– dimmer were obviously increased in critically ill patients.(2)Serum levels of CRP and D - dimer were important index for the extent of severity and prognosis in critically ill patients.