| Objective: To compare the clinical outcomes between drug-eluting stents (DES) and bare metal stents (BMS) implantation in patients with the treatment of large coronary vessels (≥3mm).Methods: A cohort of consecutive patients with single coronary lesions enrolled our hospital from 2001.12 to 2006.12 , who were treated with single stent more than 3.0mm in diameter DES(n=91) / BMS(n=70). The clinical, angiographic and procedural characteristics were compared, also the incidence of agina recurrence and major adverse cardiac events (MACE including death, reinfarction , in-stent thrombosis , restenosis rate , target vessel revascularization) up to 12 months post PCI were assessed. Some subjects received coronary angiographic follow-up.Results:1.The averge stents length was significantly longer in the group treated with DES than that of BMS(21.01±6.35mm for DES vs 17.31±4.90mm for BMS; P﹤0.05).2. The agina recurrence rate of DES was sincerely lower than that of BMS (8.7% vs 24.2%,P﹤0.01).3. The target vessel revascularization rate of DES was lower than that of BMS (3.2% vs 11.4%,P﹤0.05).4.No obvious difference was observed about the death rate and myocardial infarction rate between two groups( P>0.05).Conclusion:1.DES can dramatically reduced the agina recurrence rate and the target vessel revascularization rate in the treatment of large coronary vessels (≥3mm), but no obvious difference was observed about the death rate and myocardial infarction rate between two groups.2.We should choose DES when treat with diabetic or long lesions, diffuse lesions, small vessels and bifurcation lesions etc, because DES can significantly reduce the restenosis rates.
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