Medical Ozone Therapy Of Osteoarthritis Of The Experimental Study And Clinical Observation

Part I: Comparison of therapeutic effect medical ozone and sodium hyaluronate in the treatment of rabbit knee osteoarthritisObjectives: Through the establishment of rabbit knee osteoarthritis animal model, comparison of intra-articular injection of sodium hyaluronate or ozone therapeutic effect, to explore the availability of medical ozone therapy in osteoarthritis of the knee capacity.Methods: 24 ordinary rabbits (2.2-2.5 kg body weight, 4-5 months old) will be establishment of rabbit knee osteoarthritis that OA rabbit model was established by plaster fixation on left patella joint in a stretch of six weeks. After the OA model was duplicated, the rabbits were randomly divided into four groups (n = 6): osteoarthritis group, sodium hyaluronate group, the Medical Group ozone, a sodium hyaluronate + ozone medical group, at the same time, each group Rabbits right knee as a normal control group. The osteoarthritis group does not make processing, other three groups separately inject the sodium hyaluronate, the ozone, the ozone and the sodium hyaluronate. After 5 weeks, all experimental animal unification killed. Measured the activity of rabbits knee and done MRI Joint range of motion and MRI was estimated when the model was made and before the rabbits was killed. After the treatment expires, killed the rabbits, to take the knee joint femoral condyle spot the articular cartilage to make the pathological section, the HE dyeing observation articular cartilage general shape, safranine O dyes line of Mankin's scale.Results: 1 success duplication rabbit knee joint osseous arthritis animal model.2 joint activity inspection, the magnetic resonance inspection and the pathology inspection demonstrated after relieves the brake the osseous arthritis to continue to develop, in the articular cavity injects the ozone or (and) the sodium hyaluric may delay arthritis the development, three kind of method of treatment curative effect non-statistics significance.Conclusion: The medical ozone may reduce the inflammation, delays the cartilage to degenerate, improves the joint activity function, has the treatment function to the osteoarthritis.Part II: CT-guided injection in the knee joint medical ozone therapy of osteoarthritis of the Clinical ObservationObjective: Observes medical ozone (O3) treatment knee osseous arthritis (OA) the clinical curative effect.Methods: 20 cases of knee osteoarthritis patients, CT-guided percutaneous intra-articular injection of medical ozone. After the treatment, the treatment course had finished separately 1 month carries on the appraisal to the treatment result.Results: The patients with visual analog score (VAS) the significant differences in contrast. The knee joint function evaluation rate reach 90%, ozone therapy effectiveness are high. Conclusion: Medical ozone therapy knee osseous arthritis can relieve the joint ache effectively, improves the joint activity, the curative effect is satisfied, and operates easily, the cost low, effective quick, not obvious side effect, is one of treatment knee osteoarthritis good method.