The Imaging Study Of Opportunity Chest Infection

Partâ… CT study of Aspergillus fumigatus pneumonia models of New Zealandwhite rabbitsObjective: To summarize CT appearance of Aspergillus fumigatus pneumonia models of New Zealand white rabbits and its relation to clinical course and its relation to pathology.Materials and methods: 22 Healthy male New Zealand White rabbits were divided into two groups randomly. Experiment animals were numbered 1-20 and control animals were numbered 21 and 22. Arabinosylcytosin was administered for the first 5 days through vein according to the criteria 440mg / m² . The same dose was given every other day since the sixth day to maintain hypo-immune state. Vancocin and ceftazidime intravenous injection were given every day for 15mg / kg and 150mg/kg respectively. Gentamicin intravenous injection was adopted every other day for 5mg / kg. We use the method of per cutem puncturation aritube injection bacterium fluid 0.4 ml involvement 5×10⁷ /ml Aspergillus fumigatus ,form the animal model of pulmonary Aspergillus fumigatus. The control group received intratrachaeal injection aequale normal sodium as comparison. Lung CT scan was performed one day pre-infection and 2, 4, 6, 8, 10, 12, 14, 16, 18 post-infection. Two rabbits with abnormal CT appearance from experiment group were executed. Pathological exam and fungus cultivation were done on the sample. Analyze all the findings of pathological results, fungus cultivation and CT appearance.Results: Rabbits numbered 1,2,4,5,7,9-20 received successful injection. Abnormal CT appearances were found in all experiment rabbits in 18 days. The first time for abnormal CT appearance were recorded as follows:6 rabbits on 2^nd day, 4 on 4^th day,3 on sixth day, 2 on 8^th day, one on 12^th day, and one on 18^th day. Among them, small GGO were found in 14 cases, large GGO in 4 cases and consolidation of bilateral lungs in 2 cases. 8 of 10 Spontaneous dead rabbits were found worse situation in two consecutive CT exams. They showed as consolidation of bilateral lungs in 4 cases, GGO in 4 and nodules in 2 cases. No abnormal were detected in control group. Hemorrhage can be seen in 8 of the 12 GGO specimens. Hyperemia can be seen in 11, inflammatory cell infiltration can be seen in 9, and necrosis can be seen in 1 specimen. Hemorrhage can be seen in 5 of the 7 consolidation specimens. Hyperemia can be seen in 7, necrosis can be seen in 5, and inflammatory cell infiltration can be seen in 5 specimens. There was relatively high consistency between CT appearances and pathological findings.Conclusion: 1. Abnormal CT appearances of lung were found in one week after Aspergillus fumigarus infection in rabbits of hypo-immune state. The most common abnormal appearances were GGO in the surrounding of the lung. These abnormal appearences usually shange in a short time and sometimes disappear. As rabbits with Aspergillus fumigarus died of aggravation of infection, obvious changes in CT manifestation were found which were mainly of consolidation of bilateral lungs.2. There was relatively high consistency between CT appearance and pathological findings in the Aspergillus fumigarus pneumonia models of New Zealand white rabbits.GGO in CT represent hyperemia, hemorrhage, inflammatory cell infiltration, and interstitium hyperplasy. Consolidations in CT represent more severe hyperemia, hemorrhage, inflammatory cell infiltration, and interstitium hyperplasy than GGO and represent necrosis and abscess.Partâ…¡The imaging study of pneumonia concomitant with hematologic diseaseObjective:To summarize imaging appearance of pneumonia of the patients with hematologic diseases who are hypoimmunity. To summarize is there different imaging appearances of pneumonia concomitant with different hematologic diseases. To contrast is there imaging appearances of different pneumonia concomitant with hematologic diseases. Materials and methods:X-ray data and clinical data of 68 patients of hematologic disease concomitant with pneumonia were collected. 52 patients were bacterial pneumonia. 15 patients were pulmonary mycosis. 1 patient was viral pneumonia. CT data and clinical data of 68 patients of hematologic disease concomitant with pneumonia were collected. 30 patients are bacterial pneumonia. 22 patients were pulmonary mycosis.5 patients were tuberculosis. Establish data bank with Microsoft Excel software. Study the followings:1) the characters of imaging appearance of pneumonia of the patients with hematologic diseases who were hypoimmunity.2) contrast imaging appearance of pneumonia concomitant with different hematologic diseases.3) contrast imaging appearance of different pneumonia concomitant with hematologic diseases. SPSS 16.0 were used for statistic analysis.Results :1,the characters of imaging appearance of pneumonia of the patients with hematologic diseases who were hypoimmunity.1)X-ray data: Nodules and lumps frequency was 29.4%.GGO frequency was 47.1%o Lung marking densify frequency was 73.7%. Pleural effussion frequency was 27.9%. Pleural thickening frequency was 11.8%. Fibrosis frequency was 11.8%. Hilum pulmonis increment frequency was 14.7%. X-ray no abnormality seen frequency was 7.4%. Homogeneous appearance only frequency was 26.5%. Multitude character appearance frequency was 66.2%.2)CT data: Nodules and lumps frequency was 36.8%.GGO frequency was 73.7%. Consolidation frequency was 19.3%. Cavity frequency was 5.3%. Graticule frequency was 10.5%. Pleural effussion frequency was 36.8%. Pleural thickening frequency was 17.5%.Pericardial effusion frequency was 10.5%.2,Contrast imaging appearance of pneumonia concomitant with different hematologic diseases.1)X-ray data: There was no significant difference in nodules and lumps frequency in different hematologic diseases (χ² =3.611, P=0.164>0.05). There was also no significant difference in GGO frequency in different hematologic diseases (χ² =4.859, P=0.088>0.05) . There was also no significant difference in Lung marking densify frequency in different hematologic diseases (χ² =0.283, P=0.868>0.05) . There was also no significant difference in Pleural effussion frequency in different hematologic diseases(χ² =1.985, P=0.371>0.05) . There was also no significant difference in Consolidation frequency in different hematologic diseases (χ² =0.835, P=0.659>0.05) . There was also no significant difference in nodules and lumps single or multitude frequency in different hematologic diseases(χ² =3.342, P=0.502>0.05). There was also no significant difference in GGO single or multitude frequency in different hematologic diseases (χ² =4.370, P=0.358>0.05) . There was also no significant difference in GGO large or small frequency in different hematologic diseases (χ² =0.530, P=0.767>0.05) .2)CT data: Nodules and lumps frequency is higher in leukemia than others (χ² =4.414, P=0.040<0.05) . There was no significant difference in GGO frequency in different hematologic diseases(χ² =3.640, P=0.303>0.05). There was also no significant difference in Pleural effussion frequency in different hematologic diseases (χ² =3.640, P=0.303>0.05) . There was also no significant difference in Consolidation frequency in different hematologic diseases (χ² =1.134, P=0.769>0.05). There was also no significant difference in GGO single or multitude frequency in different hematologic diseases (χ² =2. 764, P=0. 429>0. 05) . There was also no significant difference in GGO large or small frequency in different hematologic diseases (χ² =1.264, P=0.738>0.05) .3,contrast imaging appearance of different pneumonia concomitant with hematologic diseases.1) X-ray data: There was no significant difference in nodules and lumps frequency in different lung infection (χ² =3.611, P=0.164>0.05) . There was no significant difference in GGO frequency in different lung infection (χ² =3.675, P=0.159>0.05) . There was no significant difference in Lung marking densify frequency in different lung infection (χ² =1.543, P=0.462>0.05). There was no significant difference in Pleural effussion frequency in different lung infection(χ² =0.521, P=0.771>0.05). There was no significant difference in nodules and lumps single or multitude frequency in different lung infection (χ² =0.090, P=0.956>0.05). There was no significant difference in GGO single or multitude frequency in different lung infection (χ² =2.958, P=0.228>0.05) . There was also no significant difference in GGO large or small frequency in different lung infection (χ² =2.380, P=0.130>0.05) . 2)CT data: There was no significant difference in nodules and lumps frequency in different lung infection (χ²=5.142, P=0.076>0.05) . There was no significant difference in GGO frequency in different lung infection (χ² =3.619, P=0.164>0.05) . There was also no significant difference in Consolidation frequency in different lung infection (χ 2 =2.227, P=0.328>0.05) . There was no significant difference in Pleural effussion frequency in different lung infection (χ²=1.391, P=0.499>0.05) . There was also no significant difference in GGO large or small frequency in different lung infection ((χ² =2.455, P=0.163>0.05) .Conclusion:1,The most commom appearance of pneumonia of the patients with hematologic diseases who are hypoimmunity is multitude GGO in bateral lung.Most is multitude character appearance in one patient. Nodules and lumps , fibrosis , pleural effussion are also the common appearance.2,Nodules and lumps of pneumonia of the patients with hematologic diseases who are hypoimmunity were more common in leukemia than other hematologic diseases.3,There was no significant different imaging appearance of different pneumonia concomitant with hematologic diseases.