Detection And Clinical Implication Of Thyroid Function In Patients With Metabolic Diseases

Objective To investigate thyroid function in patients with metabolic diseases(dyslipidemia and type 2 diabetes),and study the relationship between dyslipidemia,diabetes and thyroid function.Methods 412 dyslipidemic patients(dyslipidemia group:163 female, 249 male,mean age:50.7±15.7),449 T2DM patients(T2DM group:198 female,251 male,mean age:50.5±14.7)and general residents in Jiangsu province(control group:210 female,287 male,mean age:49.0±13.8) were enrolled in this study.Thyroid hormones and thyrotropin(TSH) were detected by electrochemiluminescent assay.Groups were compared for the prevalence of thyroid dysfunction and other parameters.Results Thyroid dysfunction was found in 56/497(11.2%)cases in the control group,the prevalence of hyperthyroidism,subclinical hyperthyroidddism,hypothyroidism,subclinical hypothyroidism and positivity of thyroid peroxidase antibody were 1.0%,1.4%,0.8%,8.0% and 16.0%respectively.Thyroid dysfunction was found in 71/412(17.2%)cases in the dyslipidemia group,which was significant higher than control group(P= 0.001).In the dyslipidemia group,the prevalence of hyperthyroidism, subclinical hyperthyroidism,hypothyroidism and subclinical hypothyroidism were 0.2%,2.7%,0.9%and 13.6%,respectively,with the prevalence of subclinical hypothyroidism being significantly higher than that in control group(P＜0.05).The prevalence of hypothyroidism and subclinical hypothyroidism increased with age.Female gender and decreased HDL-C level(female＜50mg/dL,male＜40mg/dL)were independent risk factors for thyroid dysfunction.Thyroid dysfunction was found in 72/449(16.1%)cases in the T2DM group,which was remarkablely higher than control group (P=0.035).In the T2DM group,the prevalence of hyperthyroidism, subclinical hyperthyroidism,hypothyroidism,subclinical hypothyroidism and positivity of thyroid peroxidase antibody were 1.2%,1.0%,1.7%, 12.2%and 24.5%,respectively,with the prevalence of subclinical hypothyroidism being significantly higher than that in control subjects (P＜0.05).The prevalence of subclinical hypothyroidism increased with age.Female gender,positivity of thyroid peroxidase antibody, FBG≥10mmol/L and poor glycemic control(HbA1c≥10%)were independent risk factors for abnomal thyroid function.Conclusions Patients with dyslipidemia and T2DM have high prevalence of thyroid dysfunction.Therefore,the thyroid function among these patients should be screened,especially in those patients with such risk factors as female gender.