Clinical Significance Of Relative Blood Serum In Flammatory Factor In Children Mycoplasma Pneumonia's

Objective:To investigate and discuss the change and the clinical significance of serum interleukin-2(IL-2),interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-12(IL-12)in children with mycoplasma pneumonia(MPP).Method:To collect 50 cases of children with MPP(28 cases of children with severe and 22 cases of children with mild)and 30 cases of healthy child -ren as contrast;To take ELISA as method to determine the ordinary pneumonia serum IL-2,IL-6,IL-8,IL-12 levels in children with MPP during severe period, mild period and convalescence period and Germany Ling BNⅡwith plasma protein analysis using scattering rate turbidime -tric method to determine the contents and composition of high -sensitivity C-reactive protein(hs-CRP), imunoglobulin(Ig)and serum complement(C).ResultDuring severe period and convalescence period,there is significant difference in IL-2,IL-12 between children with MPP and healthy children(P＜0.01,P＜0.05).Whereas during severe period,serum IL-6,IL-8 levels in children with MPP are obviously higher those in healthy children(both P＜0.01).During convalescence period,its content drops significantly(but P＞0.05).Compared the severe period and convalescence period,the difference is also obvious and significant that the serum IL-2,IL-12 decrease(P＜0.01,P＜0.05),but IL-6,IL-8 increase,(both P＜0.01).IL-2 and IL-12 in children with severe is significantly lower than those in children with mild,while serum IL-6, IL-8 slightly higher(P＜0.01,respectively).During severe period,IgM and IgG in children with MPP are significantly lower than the healthy children(P＜0.01,P＜0.05),whereas IgA decreases significantly(P＜0.05).Serum hs-CRP,C3,C4 in children with MPP are significantly higher,(P＜0.01,P＜0.01,P＜0.05).Compared the severe period and convalescence period,hs-CRP and C3 in children with MPP increase significantly(P＜0.01).IgM and IgG in children with severe increase significantly(P＜0.01,P＜0.01);while IgA decreases significantly(P＜0.05). Serum hs-CRP,C3,C4 in children with severe are significantly higher than those in healthy children(P＜0.01,respectively).Conclusion1.During severe period,cytokines IL-2,IL-12 levels in children with MPP are significantly lower,while,IL-6,IL-8 levels increases significantly.During convalescence period,cytokines IL-2,IL-12 levels in children with MPP drops significantly,but IL-6,IL-8 are nearly the same as the healthy children.The detection of these inflammatory cytokines will facilitate determining the condition and prognosis of certain clinical application.2.During severe period and convalescence period,serum hs-CRP both in children with severe and mild increases significantly.3.During severe period serum immunoglobulin IgM,IgA and complement C3,C4 in children with MPP significantly increase,while IgG decreases; During convalescence period,serum immunoglobulin IgG significantly increases,while there is no obvious change in IgM,IgA and complement C3, C4.Compared with children with mild,serum globulin IgM,IgG and hs-CRP, C3,C4 in children with severe increase significantly,while IgA decreases.The detection of immunoglobulin and complement and the corresponding effect on the immune function of Children will be of certain clinical significance.