Study On Association Of Serum C-reactive Protein, Interleukin-6and Interleukin-10Levels With COPD

Objective: To explore the relationship between serum C-reactive protein (CRP),interleukin-6(IL-6), interleukin-10(IL-10) levels and chronic obstructive pulmonarydisease (COPD).Methods:48patients with acute exacerbation of COPD from Department of RespiratoryMedicine of our hospital during September2013and February2014are chosen as an acutegroup，48cases of patients with stable chronic obstructive pulmonary disease as a stablegroup and48healthy people as a control group. All subjects meet the inclusion criteriaand exclusion criteria. There is no significant difference of age, gender, and durationamong the three groups (P>0.05). Blood samples of the three groups are collected andprocessed. The serum CRP, IL-6and IL-10levels of three groups are detected and lungfunction is measured with lung function test instruments. Statistical analysis of serum CRP,IL-6, IL-10levels and lung function in three groups are analyzed by using SPSS13.0statistical package.Results:(1) The serum CRP levels of acute group, stable group and control group are quitedifferent.(P <0.05).The IL-6levels between acute group and control group, and the onebetween stable group and control group are statistically significant (P <0.05).But thecomparison of IL-6levels between acute group and stable group is not statisticallysignificant (P>0.05). The L-10levels between acute group and control group, and the onebetween stable group and control group are statistically significant (P <0.05).But thecomparison of IL-10levels between acute group and stable group is not statisticallysignificant (P>0.05).(2) The multiple comparison of FEV1%and FEV1/FVC betweenacute group, stable group and control group are of significant difference (P <0.05).(3)There is significant correlation between the serum CRP, IL-6, IL-10levels and FEV1%,FEV1/FVC in both stable group and acute group. Conclusions:(1) The acute group has the highest levels of CRP and IL-6with the stablegroup following and the levels in control group are the lowest. However, the levels ofIL-10in each of the three groups are on the contrary. They are involved in theinflammatory response in COPD disease. There is some clinical value in analyzing thedevelopment of disease by detecting the changes of the levels of the three factors.(2) Thelevels of CRP and IL-6have a negative correlation with FEV1%、FEV1/FVC in COPDpatients while the level of IL-10has a positive correlation with FEV1%、FEV1/FVC inCOPD patients. Serum CRP, IL-6, IL-10can be used to assess the level of severity ofCOPD observed.